F. Jay Murray

TL;DR: The ARC models demonstrated a strong correlation between the predicted vs. observed values for specific sensitive endpoints of these developmental toxicities, and provide a promising approach for predicting the developmental toxicity of untested HBPS.

TL;DR: It is shown that the effects on selected repeat-dose and developmental toxicity endpoints and mutagenic activity in bacterial assays can be predicted from compositional information using models based on the aromatic-ring class profile, "ARC profile" as defined by gas chromatographic separation of the DMSO-soluble fraction of the starting materials.

TL;DR: In this article, the authors evaluated the mechanistic data related to the steps and timing of cellular events following therapeutic recommended (≤4 grams/day) and higher doses of acetaminophen that may cause hepatotoxicity to evaluate whether these changes indicate that the drug is a carcinogenic hazard.

TL;DR: The LOAEL and NOAEL for molybdenum were determined to be 60 and 17mgMo/kgbw/day, respectively, and no treatment-related adverse effects on reproductive organ weights or histopathology, estrus cycles or sperm parameters were observed at any dose level.

TL;DR: Relationships between PAC content and repeat-dose and developmental toxicities of high boiling petroleum substances (HBPS) are characterized, and statistical models that can be used to predict critical effects of similar untested substances are developed.