F
F Mandel
Researcher at Upjohn
Publications - 4
Citations - 1139
F Mandel is an academic researcher from Upjohn. The author has contributed to research in topics: Ouabain & Mass spectrometry. The author has an hindex of 3, co-authored 4 publications receiving 1110 citations.
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Journal ArticleDOI
Identification and characterization of a ouabain-like compound from human plasma
John M. Hamlyn,Mordecai P. Blaustein,Sergio Bova,Donald W. DuCharme,Douglas W. Harris,F Mandel,W R Mathews,James H. Ludens +7 more
TL;DR: In this article, a human ouabain-like compound (OLC) was identified by mass spectroscopy as an endogenous substance from human plasma that binds with high affinity to the digitalis glycosides and their aglycones.
Journal ArticleDOI
Mass spectral characterization of an endogenous digitalislike factor from human plasma.
W R Mathews,Donald W. DuCharme,John M. Hamlyn,Douglas W. Harris,F Mandel,Michael A. Clark,James H. Ludens +6 more
TL;DR: It is concluded that the endogenous digitalislike factor isolated from human plasma is ouabain or a closely related isomer.
Journal ArticleDOI
Purification of an endogenous digitalislike factor from human plasma for structural analysis.
James H. Ludens,Michael A. Clark,Donald W. DuCharme,Douglas W. Harris,B. S. Lutzke,F Mandel,W R Mathews,D M Sutter,John M. Hamlyn +8 more
TL;DR: This material may represent a plasma-borne, naturally occurring, selective, high-affinity ligand for the digitalis binding site that may play a significant role in the modulation of the sodium pump and thereby cellular electrolyte homeostasis in humans.