John M. Hamlyn

TL;DR: In this article, a human ouabain-like compound (OLC) was identified by mass spectroscopy as an endogenous substance from human plasma that binds with high affinity to the digitalis glycosides and their aglycones.

TL;DR: A highly significant correlation is demonstrated between levels of a plasma inhibitor of (Na+ + K+)ATPase activity and mean arterial blood pressure in normotensive and hypertensive individuals, providing evidence for the involvement of a circulating Na+ pump inhibitor in the genesis of essential hypertension.

TL;DR: Recent evidence is summarized that defines specific molecular links between Na(+) and the elevated vascular resistance that directly produces high BP, and several central and peripheral mechanisms are coordinated by EO to effect and maintain the salt-induced elevation of BP.

TL;DR: It is concluded that the endogenous digitalislike factor isolated from human plasma is ouabain or a closely related isomer.

TL;DR: The unanticipated lack of correlation of ouabain with atrial pressures indicates that volume is not the chief determinant of oUabain concentration in patients with congestive heart failure, but the significant relations of plasma ou abain concentration with cardiac index and mean arterial pressure imply that endogenous ouABain may be an important homeostatic factor in humans.