F
Fabian Docagne
Researcher at University of Caen Lower Normandy
Publications - 78
Citations - 5000
Fabian Docagne is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Neuroprotection & Plasminogen activator. The author has an hindex of 37, co-authored 77 publications receiving 4456 citations. Previous affiliations of Fabian Docagne include Katholieke Universiteit Leuven & University of Southampton.
Papers
More filters
Journal ArticleDOI
The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.
Olivier Nicole,Fabian Docagne,Carine Ali,Isabelle Margaill,Peter Carmeliet,Eric T. MacKenzie,Denis Vivien,Alain Buisson +7 more
TL;DR: It is reported for the first time that t-PA potentiates signaling mediated by glutamatergic receptors by modifying the properties of the N-methyl-D-aspartate (NMDA) receptor.
Journal ArticleDOI
Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis
Cristina Benito,Juan Pablo Romero,Rosa M. Tolón,Diego Clemente,Fabian Docagne,Cecilia J. Hillard,Carmen Guaza,Julián Romero +7 more
TL;DR: As seen for other neuroinflammatory conditions, selective glial expression of cannabinoid CB1 and CB2 receptors and FAAH enzyme is induced in MS, thus supporting a role for the endocannabinoid system in the pathogenesis and/or evolution of this disease.
Journal ArticleDOI
Neuroprotection Mediated by Glial Cell Line-Derived Neurotrophic Factor: Involvement of a Reduction of NMDA-Induced Calcium Influx by the Mitogen-Activated Protein Kinase Pathway
Olivier Nicole,Carine Ali,Fabian Docagne,Laurent Plawinski,Eric T. MacKenzie,Denis Vivien,Alain Buisson +6 more
TL;DR: A novel mechanism by which the activation of MAPK induced by GDNF modulates NMDA receptor activity is described, a mechanism that could be responsible for the neuroprotective effect of GDNF in acute brain injury.
Journal ArticleDOI
Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain
Carine Ali,Olivier Nicole,Fabian Docagne,Sylvain Lesné,Eric T. MacKenzie,André Nouvelot,Alain Buisson,Denis Vivien +7 more
TL;DR: The results suggest that the up-regulation of IL-6 induced by cerebral ischemia could represent an endogenous neuroprotective mechanism against NMDA receptor-mediated injury.
Journal ArticleDOI
Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier.
Silke Krol,Richard Macrez,Fabian Docagne,Gilles Defer,Sophie Laurent,Masoud Rahman,Mohammad Javad Hajipour,Patrick G. Kehoe,Morteza Mahmoudi +8 more