Fabiana K. Ludka

TL;DR: GUO affords neuroprotection of hippocampal slices subjected to OGD by a mechanism that implicates the following: prevention of mitochondrial membrane depolarization, reduction of oxidative stress, regulation of inflammation by inhibition of nuclear factor kappa B and inducible nitric oxide synthase, and promoting glutamate uptake.

TL;DR: It is demonstrated that atorvastatin exerts an antidepressant-like effect and point to dependence on the inhibition of NMDA receptors and NO-cGMP synthesis, and on the increase of hippocampal BDNF levels.

TL;DR: Results suggest an involvement of the PI3K/Akt/GSK-3β/mTOR signaling pathway in the antidepressant-like effect of atorvastatin in mice.

TL;DR: The results indicate that the antidepressant-like effect of creatine in the TST depends on the activation of Akt, Nrf2/HO-1, GPx, and mTOR, and GSK3 inhibition.

TL;DR: Investigating the neuroprotective effect of creatine and PCr against 6-hydroxydopamine (6-OHDA)-induced mitochondrial dysfunction and cell death in rat striatal slices found they minimize oxidative stress in striatum to afford neuroprotection of dopaminergic neurons.