Mauricio P. Cunha

TL;DR: The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.

TL;DR: The results indicated the antidepressant-like effect of the ethanolic extract of S. molle in the tail suspension test may be dependent on the presence of rutin that likely exerts its antidepressant- like effect by increasing the availability of serotonin and noradrenaline in the synaptic cleft.

TL;DR: The results indicate that scopoletin's antidepressant-like effect is dependent on the serotonergic (5-HT(2A) receptors), noradrenergic (alpha(1)- and alpha(2)-adrenoceptors) and dopaminergic (dopamine D(1) and D(2) receptors) systems.

TL;DR: In this study, zinc chloride was given alone or in combination with different classes of antidepressants by oral route to mice and the behavioral response in the tail suspension test (TST), a predictive test of antidepressant action, was investigated, suggesting that an improvement in the response to the antidepressant therapy occurs when zinc is combined with differentclasses of antidepressants.

TL;DR: It is suggested that carnosol and betulinic acid could be responsible for the anti-immobility effect of extracts from R. officinalis, and the effects in the tail suspension test are specific.