Fabien Lecomte

TL;DR: In this paper, the compound was synthesized in 29 linear steps and 3% overall yield starting from a known oxazoline readily available from L-threonine, which was used to synthesize the compound.

TL;DR: A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders as discussed by the authors.

TL;DR: A series of substituted 3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders as mentioned in this paper.

TL;DR: Aryl Grignard reagents react stereospecifically with alkenyl halides in the presence of manganese chloride to afford good yields of cross-coupling products.

TL;DR: A series of 4-azaindole inhibitors of c-Met kinase was described and the postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure.