F
Fabio Apone
Researcher at Arena Pharmaceuticals, Inc.
Publications - 31
Citations - 904
Fabio Apone is an academic researcher from Arena Pharmaceuticals, Inc.. The author has contributed to research in topics: G protein-coupled receptor & Heterotrimeric G protein. The author has an hindex of 14, co-authored 30 publications receiving 633 citations.
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Journal ArticleDOI
New Trends in Cosmetics: By-Products of Plant Origin and Their Potential Use as Cosmetic Active Ingredients
TL;DR: In this article, the potentialities and the current use of compounds and extracts deriving from agronomical disposable wastes in the cosmetic field are discussed, and if the waste products come from organic farming, they are even more valuable source of safe extracts for Cosmetics, since they lack any residual pesticide or potentially toxic chemical.
Journal ArticleDOI
GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering
TL;DR: Overexpression of GCR1 in tobacco (Nicotiana tabacum) BY-2 cells caused an increase in thymidine incorporation and in the mitotic index of aphidicolin synchronized cells, consistent with the hypothesis that GCR 1 may be a regulator of the cell cycle and that this regulation underlies the developmental changes observed in the G CR1 transformants.
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The G-Protein-Coupled Receptor GCR1 Regulates DNA Synthesis through Activation of Phosphatidylinositol-Specific Phospholipase C
Fabio Apone,Nicole Alyeshmerni,Kathryn Wiens,Derek Chalmers,Maarten J. Chrispeels,Gabriella Colucci +5 more
TL;DR: GCR1-enhanced thymidine incorporation into DNA depends on an increase in phosphatidylinositol-specific phospholipase C activity and an elevation of inositol 1,4,5-trisphosphate levels in the cells, suggesting that GCR1 and GPA1 are both involved in this particular signaling pathway.
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Plant Cell Cultures as Source of Cosmetic Active Ingredients
TL;DR: The aim of the present review is to focus on the successful research accomplishments in the development of plant cell cultures for the production of active ingredients for cosmetic applications.
Journal ArticleDOI
Chestnut (Castanea sativa Mill.) industrial wastes as a valued bioresource for the production of active ingredients
Giuseppe Squillaci,Fabio Apone,Luigi Michele Sena,Antonietta Carola,Annalisa Tito,Marida Bimonte,Adriana De Lucia,Gabriella Colucci,Francesco La Cara,Alessandra Morana +9 more
TL;DR: In this article, a blend of inner and outer chestnut shells (IOCS), and inner chestnut shell (ICS) were extracted through an eco-friendly method, and the results suggest that chestnut-shell extracts can be potential active ingredients for cosmetic formulations devoted to the skin protection.