F
Fan Xia
Researcher at Baylor College of Medicine
Publications - 109
Citations - 9911
Fan Xia is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Exome sequencing & Exome. The author has an hindex of 40, co-authored 97 publications receiving 7939 citations. Previous affiliations of Fan Xia include Harvard University & University of Rochester Medical Center.
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Journal ArticleDOI
Clinical whole-exome sequencing for the diagnosis of mendelian disorders.
Yaping Yang,Donna M. Muzny,Jeffrey G. Reid,Matthew N. Bainbridge,Alecia Willis,Patricia A. Ward,Alicia Braxton,Joke Beuten,Fan Xia,Zhiyv Niu,Matthew T. Hardison,Richard E. Person,Mir Reza Bekheirnia,Magalie S. Leduc,Amelia Kirby,Peter Pham,Jennifer Scull,Min Wang,Yan Ding,Sharon E. Plon,James R. Lupski,Arthur L. Beaudet,Richard A. Gibbs,Christine M. Eng +23 more
TL;DR: W whole-exome sequencing identified the underlying genetic defect in 25% of consecutive patients referred for evaluation of a possible genetic condition.
Journal ArticleDOI
Molecular Findings Among Patients Referred for Clinical Whole-Exome Sequencing
Yaping Yang,Donna M. Muzny,Fan Xia,Zhiyv Niu,Richard E. Person,Yan Ding,Patricia A. Ward,Alicia Braxton,Min Wang,Christian J. Buhay,Narayanan Veeraraghavan,Alicia Hawes,Theodore Chiang,Magalie S. Leduc,Joke Beuten,Jing Zhang,Weimin He,Jennifer Scull,Alecia Willis,Megan Landsverk,William J. Craigen,Mir Reza Bekheirnia,Asbjørg Stray-Pedersen,Pengfei Liu,Shu Wen,Wendy Alcaraz,Hong Cui,Magdalena Walkiewicz,Jeffrey G. Reid,Matthew N. Bainbridge,Ankita Patel,Eric Boerwinkle,Eric Boerwinkle,Arthur L. Beaudet,James R. Lupski,Sharon E. Plon,Richard A. Gibbs,Christine M. Eng +37 more
TL;DR: Whole-exome sequencing provided a potential molecular diagnosis for 25% of a large cohort of patients referred for evaluation of suspected genetic conditions, including detection of rare genetic events and new mutations contributing to disease, and may offer advantages over traditional molecular diagnostic approaches in certain patients.
Journal ArticleDOI
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
Dawang Zhou,Claudius Conrad,Fan Xia,Ji Sun Park,Bernhard Payer,Yi Yin,Gregory Y. Lauwers,Wolfgang Thasler,Jeannie T. Lee,Joseph Avruch,Nabeel Bardeesy +10 more
TL;DR: Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila and Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC.
Journal ArticleDOI
Resolution of Disease Phenotypes Resulting from Multilocus Genomic Variation
Jennifer E. Posey,Tamar Harel,Pengfei Liu,Jill A. Rosenfeld,Regis A. James,Zeynep Coban Akdemir,Magdalena Walkiewicz,Weimin Bi,Rui Xiao,Yan Ding,Fan Xia,Arthur L. Beaudet,Donna M. Muzny,Richard A. Gibbs,Eric Boerwinkle,Christine M. Eng,V. Reid Sutton,Chad A. Shaw,Sharon E. Plon,Sharon E. Plon,Yaping Yang,James R. Lupski,James R. Lupski +22 more
TL;DR: The results show that structured clinical ontologies can be used to determine the degree of overlap between two mendelian diseases in the same patient; the diseases can be distinct or overlapping.
Journal ArticleDOI
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
TL;DR: It is established that MST1 and MST2 are activated in mitosis and catalyze the mitotic phosphorylation of MOBKL1A/MOBkL1B, which is sufficient to accelerate cell proliferation substantially by speeding progression through G1/S as well as mitotic exit.