Showing papers in "Cancer Cell in 2009"

TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.

TL;DR: It is reported that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis.

TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.

TL;DR: It is reported that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in various metastasis assays, including after intravenous injection of tumor cells or after removal of primary orthotopically grown tumors.

TL;DR: It is demonstrated that hypoxia-inducible factor HIF2alpha and multiple HIF-regulated genes are preferentially expressed in GSCs in comparison to non-stem tumor cells and normal neural progenitors.

TL;DR: Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior.

TL;DR: A critical role for LOX in premetastatic niche formation is demonstrated and support is provided for targeting LOX for the treatment and prevention of metastatic disease.

TL;DR: Design and preclinical evaluation of AP24534, a potent, orally available multitargeted kinase inhibitor active against T315I and other BCR-ABL mutants, and clinical evaluation ofAP24534 as a pan-BCR-ABl inhibitor for treatment of CML are reported.

TL;DR: Conjugation to iRGD significantly improved the sensitivity of tumor-imaging agents and enhanced the activity of an antitumor drug.

TL;DR: A link comprising the gp130/Stat3 transcription factor signaling axis is established comprising the common tumor cell-autonomous mechanism that bridges chronic inflammation to tumor promotion in colitis-associated cancer models.

TL;DR: Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila and Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC.

TL;DR: It is reported that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells, and it is demonstrated that the MET oncogene is involved in miR+222 activation through the c-Jun transcription factor.

TL;DR: A mechanism of action for trastuzumab whereby antibody treatment disrupts ligand-independent HER2/HER3 interactions in HER2-amplified cells is described, leading to downregulation of proximal and distal AKT signaling, and correlates with the antiproliferative effects of trastzumab.

TL;DR: Findings indicate that epithelial differentiation and tumor cell viability are associated, and that EMT regulators in "K-Ras-addicted" cancers represent candidate therapeutic targets.

TL;DR: It is demonstrated that Snail-induced EMT accelerates cancer metastasis through not only enhanced invasion but also induction of immunosuppression, and inhibited tumor growth and metastasis following increase of tumor-specific tumor-infiltrating lymphocytes and systemic immune responses.

TL;DR: It is found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pathway, which is required for the induction of COP9 signalosome 2 (CSN2), which blocks the ubiquitination and degradation of Snail.

TL;DR: It is reported that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer, independent of hormone receptor status or breast cancer subtype.

TL;DR: It is shown that FKBP51 acts as a scaffolding protein for Akt and PHLPP and promotes dephosphorylation of Akt, and is downregulated in pancreatic cancer tissue samples and several cancer cell lines.

TL;DR: It is demonstrated in vivo that transformed cells and their progeny undergo infiltration and multilineage differentiation during tumorigenesis, thus identifying a pretumorigenic cell population.

TL;DR: It is reported that Orai1 and STIM1, both of which are involved in store-operated calcium entry, are essential for breast tumor cell migration in vitro and tumor metastasis in mice.

TL;DR: It is shown here that maintenance of NF-kappaB activity in tumors requires Stat3, which is also frequently constitutively activated in cancer, and is central to both the transformed and nontransformed elements in tumors.

TL;DR: It is shown that platelet-derived growth factor C (PDGF-C) is upregulated in TAFs from resistant tumors and suggested that some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF- C.

TL;DR: The importance of the interleukin-6 family of proinflammatory cytokines and their downstream effector STAT3 in colitis-associated colon cancer is demonstrated.

TL;DR: It is shown that inducible expression of Braf(V600E) off the endogenous Braf gene in mouse melanocytes stimulates skin hyperpigmentation and the appearance of nevi harboring senescent melanocytes.

TL;DR: The essential role of Stat3 downstream of Jaks is demonstrated by inhibition of tumor growth using short hairpin RNA targeting Stat3, supporting a key role of Jak kinase activity in Stat3-dependent tumorigenesis.

TL;DR: It is shown that PRIMA-1 is converted to compounds that form adducts with thiols in mutant p53, which is sufficient to induce apoptosis in tumor cells and facilitate the design of more potent and specific mutant p 53-targeting anticancer drugs.

TL;DR: The results show that TGF-beta and LIF have an essential role in the regulation of GICs in human glioblastoma.

TL;DR: The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of Ribosomal biogenesis.

TL;DR: This paper showed that SGK3 undergoes PI3K-and PDK1-dependent activation in PIK3CA mutant cancer cells and showed that these cells retain robust PDK 1 activation and membrane localization and exhibit dependency on the SGK 1 substrate SGK 3.

TL;DR: AURKA is identified as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN, and Aurora A has a critical function in regulating turnover of the N-Myc protein.