Fang-Fang Peng

TL;DR: It is shown that, although the caveolin-1 protein level had no significant change, the PKC-β-specific inhibitor LY-333531 blocked cavelin-1 Y14 phosphorylation in high glucose (HG)-treated MCs and in the renal cortex of diabetic rats, and Caveolin- 1 is thus an important mediator of the profibrogenic process in diabetic renal disease.

TL;DR: The present study demonstrates that in addition to transient EGFR transactivation, TGF-β1 can also induce continuous EG FR transactivation by a non-ligand-dependent pathway in rat mesangial cells, and raises the possibility that targeting EGFR may provide a viable alternative strategy for inhibiting T GF-β in chronic kidney disease.

TL;DR: Intermittent administration of PTHrP (1-34) exhibited an inhibitory effect on alveolar bone resorption and the gingival inflammation in periodontal tissues of diabetic rats.

TL;DR: The results showed that PTH pretreatment prevented TGF-β1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h and PTH1R associated with TβR II and both receptors internalized into the cytoplasm when mesangial cells were stimulated with PTH alone.

TL;DR: Results provide the first evidence for the HG-induced RCAN1.4 up-regulation involving increased mitochondrial fragmentation, leading to matrix protein up- Regulation, in rat glomerular mesangial cells.