F
Fang Han
Researcher at Weifang Medical University
Publications - 51
Citations - 912
Fang Han is an academic researcher from Weifang Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 30 publications receiving 527 citations. Previous affiliations of Fang Han include University of Mississippi Medical Center.
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Journal ArticleDOI
Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice.
Xiaodong Sun,Fang Han,Qingguo Lu,Qingguo Lu,Xuan Li,Di Ren,Di Ren,Jingwen Zhang,Jingwen Zhang,Ying Han,Ying Han,Yang Kevin Xiang,Ji Li +12 more
TL;DR: EMPA improved obesity-related cardiac dysfunction via regulating Sestrin2-mediated AMPK-mTOR signaling and maintaining redox homeostasis and provides a novel mechanism for the cardiovascular protection of SGLT2i in obesity.
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Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway
TL;DR: Evidence is provided that irisin improves endothelial function in aortas of high-fat-diet-induced obese mice and the mechanism for this protective effect is related to the activation of the AMPK-eNOS signaling pathway.
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SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion.
Ying Han,Weiju Sun,Di Ren,Jingwen Zhang,Zhibin He,Julia Fedorova,Xiaodong Sun,Fang Han,Ji Li +8 more
TL;DR: Results indicate that SIRT1 agonism can inhibit activation of NLRP3 inflammasome via Akt-dependent metabolic regulation during ischemic insults by I/R.
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The relationship between circulating irisin levels and endothelial function in lean and obese subjects
TL;DR: The objective of the study was to determine whether circulating irisin levels are related to endothelial dysfunction in obese subjects.
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Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice
TL;DR: Irisin improved the anti-contractile properties of PVAT from the thoracic aorta in diet-induced obese mice and the mechanism for protective effects of irisin appeared to be related to upregulation of the HO-1/adiponectin axis in PVAT and browning of PVat.