F
Fang-Yen Li
Researcher at Academia Sinica
Publications - 4
Citations - 56
Fang-Yen Li is an academic researcher from Academia Sinica. The author has contributed to research in topics: Galectin & Gene. The author has an hindex of 3, co-authored 3 publications receiving 29 citations. Previous affiliations of Fang-Yen Li include National Taiwan University.
Papers
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Journal ArticleDOI
Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner.
Fang-Yen Li,I-Chun Weng,Chun-Hung Lin,Mou-Chieh Kao,Ming-Shiang Wu,Huan Yuan Chen,Fu-Tong Liu,Fu-Tong Liu +7 more
TL;DR: It is found that H. pylori infection triggers intracellular galectin-8 aggregation in human-derived AGS gastric epithelial cells, and that these aggregates colocalize with lysosomes, and this aggregation is markedly reduced following the attenuation of host O-glycan processing.
Book ChapterDOI
Galectins in Host Defense Against Microbial Infections.
TL;DR: Galectins are differentially expressed in a variety of cell types, including immune cells, and characterized by the affinity for β-galactoside-containing glycans as discussed by the authors.
Journal ArticleDOI
Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses.
TL;DR: Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis as mentioned in this paper, and they bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles.
Book ChapterDOI
Visualization of Cytosolic Galectin Accumulation Around Damaged Vesicles and Organelles.
TL;DR: Methods for studying three disruptive substances: photosensitizers, Listeria monocytogenes, and Helicobacter pylori are described and the tools used for the detection of cytosolic galectin accumulation around damaged vesicles are summarized.