Fanny Guzman

TL;DR: Two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers are described.

TL;DR: In this article, the authors showed that immunization with molecules of relative molecular mass (Mr) 155,000 (155K) 83K, 55K and 35K, specific for the late schizont and merozoite stages of Plasmodium falciparum, could elicit either partial or total protection in Aotus trivirgatus monkeys experimentally infected with P. falcipparum.

TL;DR: Results show that peptides based on conserved and dimorphic regions of MSP‐1, interact with human red blood cells (RBCs), and showed that the RBC receptors are not sialic acid dependent and appear to be proteic in nature.

TL;DR: The similar pattern of T-cell reactivity found with both peripheral blood and heart-infiltrating T cells is consistent with the migration of M-protein-sensitized T cells to the heart tissue.

TL;DR: In this paper, the authors determined the minimal infective dose of the P falciparum FVO strain, the kinetics of the immune response induced by vaccination with the synthetic peptide mixture (S7 + S12 + S17) or the synthetic hybrid polymeric protein SPf66, and the induction of protective immunity against the experimental challenge with 2 P falcomus FVO strains.