L
Luis E. Rodríguez
Researcher at National University of Colombia
Publications - 47
Citations - 1176
Luis E. Rodríguez is an academic researcher from National University of Colombia. The author has contributed to research in topics: Plasmodium falciparum & Peptide sequence. The author has an hindex of 20, co-authored 47 publications receiving 1151 citations.
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Journal ArticleDOI
Identification of Plasmodium falciparum MSP-1 peptides able to bind to human red blood cells.
Mauricio Urquiza,Luis E. Rodríguez,Jorge Suárez,Fanny Guzman,Marisol Ocampo,Hernando Curtidor,Cesar Segura,Esperanza Trujillo,Manuel E. Patarroyo +8 more
TL;DR: Results show that peptides based on conserved and dimorphic regions of MSP‐1, interact with human red blood cells (RBCs), and showed that the RBC receptors are not sialic acid dependent and appear to be proteic in nature.
Journal ArticleDOI
Plasmodium falciparum EBA-175 kDa protein peptides which bind to human red blood cells
Luis E. Rodríguez,Mauricio Urquiza,Marisol Ocampo,Jorge Suárez,Hernando Curtidor,Fanny Guzman,Luis Eduardo Vargas,M. Triviños,M. Rosas,Manuel E. Patarroyo +9 more
TL;DR: Using synthetic peptides and specific receptor-ligand interaction methodology, 6 high-activity binding sequences from the EBA-175 CAMP strain are identified and several of these peptides are located in regions recognized by protective immune clusters of merozoites eluted antibodies.
Journal ArticleDOI
Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design.
Luis E. Rodríguez,Hernando Curtidor,Mauricio Urquiza,Gladys Cifuentes,Claudia Reyes,Manuel E. Patarroyo +5 more
TL;DR: The results show that Merozoite Surface Protein-9 (MSP-9) or Acid Basic Repeat Antigen (ABRA) 3679 is superior to other MSPs tested on the basis of its ability to bind to EMTs.
Journal ArticleDOI
Plasmodium vivax MSP-1 peptides have high specific binding activity to human reticulocytes.
Luis E. Rodríguez,Mauricio Urquiza,Marisol Ocampo,Hernando Curtidor,Jorge Suárez,Javier García,Ricardo Vera,Alvaro Puentes,Ramses López,Martha Pinto,Zuly Rivera,Manuel E. Patarroyo +11 more
TL;DR: Interestingly, some high activity binding peptides (HABPs) are located close to the hypothesised 42 and 19kDa fragment cleavage sites for this protein, suggesting that these sequences have an important role in target cell attachment and invasion process by Pv-MSP-1.
Journal ArticleDOI
Two MSA 2 peptides that bind to human red blood cells are relevant to Plasmodium falciparum merozoite invasion.
Marisol Ocampo,Mauricio Urquiza,Fanny Guzman,Luis E. Rodríguez,Jorge Suárez,Hernando Curtidor,Jaiver E. Rosas,M. Diaz,Manuel E. Patarroyo +8 more
TL;DR: Both of these sequences inhibit in vitro erythrocyte parasite invasion by up to 95% suggesting that they have an important role in the parasite's invasion process.