Natural biodegradable polymers based nano-formulations for drug delivery: A review.

A pH and NH3 sensing intelligent film based on Artemisia sphaerocephala Krasch. gum and red cabbage anthocyanins anchored by carboxymethyl cellulose sodium added as a host complex

Preparation, physicochemical and biological evaluation of quercetin based chitosan-gelatin film for food packaging

Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated.

Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing

Recently, flexible, injectable, and strain-sensitive hydrogels have attracted great research interest for application as electronic skin and wearable strain sensors. The synergistic integration of high flexibility, rapid self-healing, and antifreezing properties makes injectable, strain-sensitive, and self-healing guar gum hydrogels still a great challenge. Here, inspired by the strong hydrogen bonding of glycerol and water, the chelation cross-linking between glycerol and borax, we constructed a compact three-dimensional dynamic cross-linked net formed of glycerol-water-borax. Under stress, dynamic interactions of glycerol-water-borax net act as sacrificial bond energy for effective dissipation, which enables the hydrogel to achieve high flexibility, stretchability, and injectability. More importantly,because of the presence of glycerol, the antifreeze and moisturizing properties of the gel are improved. The hydrogel also exhibited an ultrafast self-healing ability of only 15 s. In addition, the results show that the hydrogel has self-adhesive properties and strain sensitivity. The hydrogels have the potential to be used to make flexible, wearable, and 3D-printable electronic skin and strain-sensitive sensors.

Ultraflexible Self-Healing Guar Gum-Glycerol Hydrogel with Injectable, Antifreeze, and Strain-Sensitive Properties.

Wound healing is an innate physiological response that helps restore cellular and anatomic continuity of a tissue. Selective biodegradable and biocompatible polymer materials have provided useful scaffolds for wound healing and assisted cellular messaging. In the present study, guar gum, a polymeric galactomannan, was intrinsically modified to a new cationic biopolymer guar gum alkylamine (GGAA) for wound healing applications. Biologically synthesized silver nanoparticles (Agnp) were further impregnated in GGAA for extended evaluations in punch wound models in rodents. SEM studies showed silver nanoparticles well dispersed in the new guar matrix with a particle size of ~18 nm. In wound healing experiments, faster healing and improved cosmetic appearance were observed in the new nanobiomaterial treated group compared to commercially available silver alginate cream. The total protein, DNA, and hydroxyproline contents of the wound tissues were also significantly higher in the treated group as compared with the silver alginate cream (). Silver nanoparticles exerted positive effects because of their antimicrobial properties. The nanobiomaterial was observed to promote wound closure by inducing proliferation and migration of the keratinocytes at the wound site. The derivatized guar gum matrix additionally provided a hydrated surface necessary for cell proliferation.

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Farooque Abdullah

Papers

New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications

Edible nano-bio-composite film cargo device for food packaging applications

Cationic guar gum orchestrated environmental synthesis for silver nano-bio-composite films.

Fabrication and fluorescent labeling of guar gum nanoparticles in a surfactant free aqueous environment

Synthesis of Guar gum Propionate Nanoparticles for Antimicrobial Applications