https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

A review on the dietary flavonoid kaempferol.

The relationship between peptide structure and antibacterial activity

IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

The Wealth of India

Isolation, purification, structural elucidation and antimicrobial activities of kocumarin, a novel antibiotic isolated from actinobacterium Kocuria marina CMG S2 associated with the brown seaweed Pelvetia canaliculata.

A new triterpene, perovskone (1) with a novel carbon skeleton, was isolated from the whole plant of Perovskia abrotanoides (Labiatae). The structure of 1 was established on the basis of 2D NMR spectroscopic studies and single-crystal X-ray diffraction analysis. A possible biogenetic route for 1 was also suggested

Perovskone : a triterpene with a novel carbon skeleton from Perovskia abrotanoides

A novel compound designated zafrin [4β-methyl-5, 6, 7, 8 tetrahydro-1 (4β-H)-phenanthrenone] was isolated from a crude extract of a marine bacterium identified as Pseudomonas stutzeri . Zafrin showed strong antibacterial activity against both Gram-positive and Gram-negative bacteria. The compound was purified and its structure was elucidated by spectroscopic methods including 1H-nuclear magnetic resonance (NMR), 13C-NMR, 1D-NMR and 2D-NMR spectroscopy. It could be demonstrated that a purified solution of zafrin was active against several human pathogens, including Staphylococcus aureus , and Salmonella typhi . By contrast, zafrin did not inhibit the growth of eukaryotic organisms Candida albicans and Schizosaccharomyces pombe . The minimal inhibitory concentration for Gram-positive bacteria ranged from 50 to 75 μg mL−1 and varied between 75 and 125 μg mL−1 for Gram-negative bacteria. Zafrin lysed Bacillus subtilis cells grown in an osmotically protected medium, suggesting that it does not act upon the cell wall. Further investigation using B. subtilis indicated that the compound is bactericidal and is likely to target the cell membrane.

The isolation, purification and biological activity of a novel antibacterial compound produced by Pseudomonas stutzeri.

A new triterpene, nepehinol, has been isolated from the medicinal plant NEPETA HINDOSTANA The structure 3beta-hydroxy-18beta, 19alpha H-lup-20 (19)-ene has been suggested for it

Faryal Vali Mohammad

Papers

Isolation, purification, structural elucidation and antimicrobial activities of kocumarin, a novel antibiotic isolated from actinobacterium Kocuria marina CMG S2 associated with the brown seaweed Pelvetia canaliculata.

Perovskone : a triterpene with a novel carbon skeleton from Perovskia abrotanoides

The isolation, purification and biological activity of a novel antibacterial compound produced by Pseudomonas stutzeri.

Nepehinol - a new Triterpene from Nepeta Hindostana.

A bidesmosidic hederagenin hexasaccharide from the roots of Symphytum officinale.