F
Fatemeh Poorrajab
Researcher at University of Tehran
Publications - 13
Citations - 374
Fatemeh Poorrajab is an academic researcher from University of Tehran. The author has contributed to research in topics: Leishmania major & Biological activity. The author has an hindex of 9, co-authored 13 publications receiving 332 citations.
Papers
More filters
Journal ArticleDOI
Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation.
Fatemeh Poorrajab,Sussan Kabudanian Ardestani,Saeed Emami,Mina Behrouzi-Fardmoghadam,Abbas Shafiee,Alireza Foroumadi +5 more
TL;DR: A series of 1-[5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol- 2-yl]-4-aroylpiperazines synthesized and evaluated in vitro against Leishmania major exhibited good anti-leishmanial activity against the promastigote form of L. major at non-cytotoxic concentrations.
Journal ArticleDOI
Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity.
Alireza Foroumadi,Saeed Emami,Maedeh Sorkhi,Maryam Nakhjiri,Zohreh Nazarian,Samaneh Heydari,Sussan K. Ardestani,Fatemeh Poorrajab,Abbas Shafiee +8 more
TL;DR: Results from in vitro biological assays indicated that chloro‐substituted 1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3-phenylpropen‐1‐ones exhibited excellent activity against Leishmania major at non‐cytotoxic concentrations.
Journal ArticleDOI
Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines.
Mina Behrouzi-Fardmoghadam,Fatemeh Poorrajab,Sussan K. Ardestani,Saeed Emami,Abbas Shafiee,Alireza Foroumadi +5 more
TL;DR: Most of the synthesized compounds exhibited potent anti-leishmanial activity against both promastigotes and amastigote forms of Leishmania major at non-cytotoxic concentrations.
Journal ArticleDOI
Novel antileishmanial chalconoids: synthesis and biological activity of 1- or 3-(6-chloro-2H-chromen-3-yl)propen-1-ones.
Zohreh Nazarian,Saeed Emami,Samaneh Heydari,Sussan K. Ardestani,Maryam Nakhjiri,Fatemeh Poorrajab,Abbas Shafiee,Alireza Foroumadi +7 more
TL;DR: The results of cytotoxicity assessment against mouse peritoneal macrophage cells showed that these compounds display antileishmanial activity at non-cytotoxic concentrations.
Journal ArticleDOI
Selective leishmanicidal effect of 1,3,4-thiadiazole derivatives and possible mechanism of action against Leishmania species.
Fatemeh Poorrajab,Sussan K. Ardestani,Alireza Foroumadi,Saeed Emami,Amina Kariminia,Mina Behrouzi-Fardmoghadam,Abbas Shafiee +6 more
TL;DR: The findings showed that at least part of leishmaniacidal effect of the compounds could be attributed to disruption DNA-relaxed activities of topoisomerases I and II, and cleavable-complex formation.