F
Fatemeh Safi
Researcher at Lund University
Publications - 10
Citations - 82
Fatemeh Safi is an academic researcher from Lund University. The author has contributed to research in topics: Haematopoiesis & Medicine. The author has an hindex of 2, co-authored 5 publications receiving 52 citations.
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Journal ArticleDOI
Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2.
TL;DR: A new approach is described, based on optogenetics, that enables specific investigation of β-cells in intact islets in type 2 diabetes with high time-resolution and cell-specificity and indicates that high-fat feeding leads to a compensatory potentiation of the Ca2+ response inβ-cells.
Journal ArticleDOI
S100A6 is a critical regulator of hematopoietic stem cells.
Tan Hooi Min Grahn,Abhishek Niroula,Ákos Végvári,Leal Oburoglu,Maroulio Pertesi,Sarah Warsi,Fatemeh Safi,Natsumi Miharada,Sandra C. Garcia,Kavitha Siva,Yang Liu,Emma Rörby,Björn Nilsson,Roman A. Zubarev,Stefan Karlsson +14 more
TL;DR: It is shown that p-Akt is the prime downstream mechanism of S100A6 in the regulation of HSC self-renewal by specifically governing mitochondrial metabolic function and Hsp90 protein quality and that Akt activator SC79 reverts the levels of intracellular and mitochondrial calcium in HSC.
Posted ContentDOI
Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy
Mikael Sommarin,Parashar Dhapola,Fatemeh Safi,Rebecca Warfvinge,Geironson Ulfsson L,Eva Erlandsson,Konturek-Ciesla A,Krishna Thakur R,Charlotta Böiers,David Bryder,Göran Karlsson +10 more
TL;DR: In this article, a pseudotime ordering of both mRNA and chromatin data revealed a bifurcation of megakaryocyte/erythroid and lympho/myeloid trajectories immediately downstream a subpopulation with an HSC-specific enhancer signature.
Journal ArticleDOI
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations.
TL;DR: The approach described herein allows for sensitive measurement of mRNA expression for a panel of pre-selected genes with the possibility to develop protocols for subsequent prospective isolation of molecularly distinct subpopulations.
Journal ArticleDOI
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction.
Fatemeh Safi,Parashar Dhapola,Sarah Warsi,Mikael Sommarin,Eva Erlandsson,Jonas Ungerbäck,Rebecca Warfvinge,Ewa Sitnicka,David Bryder,Charlotta Böiers,Ram Krishna Thakur,Göran Karlsson +11 more
TL;DR: LaLaurenti et al. as mentioned in this paper investigated single-cell chromatin accessibility of Lineage−, cKit+, and Sca1+ (LSK) HSPCs spanning the early differentiation landscape.