F
Fatima Smih
Researcher at French Institute of Health and Medical Research
Publications - 46
Citations - 2467
Fatima Smih is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Heart failure & Adipose tissue. The author has an hindex of 17, co-authored 45 publications receiving 2289 citations. Previous affiliations of Fatima Smih include Paul Sabatier University & Kettering University.
Papers
More filters
Journal ArticleDOI
Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.
TL;DR: Specific DSBs are created in mouse chromosomes for the first time, using an expression system for a rare-cutting endonuclease, I-SceI, and are apparently recombinogenic, stimulating gene targeting of a homologous fragment by more than 2 orders of magnitude.
Journal ArticleDOI
Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells
TL;DR: A mammalian expression vector for a modified form of I-Sce I, a yeast mitochondrial intron-encoded endonuclease with an 18-bp recognition sequence will provide a powerful approach to studying a number of molecular processes in mammalian cells, including homologous recombination.
Journal ArticleDOI
Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells
TL;DR: In this article, the I-Scel endonuclease was used to induce double-strand break (DSB) lesions in yeast, Drosophila and Caenorhabditis elegans.
Journal Article
Semicarbazide-Sensitive Amine Oxidase Substrates Stimulate Glucose Transport and Inhibit Lipolysis in Human Adipocytes
Nathalie Morin,Jose M. Lizcano,E. Fontana,Luc Marti,Fatima Smih,Philippe Rouet,D. Prévot,Antonio Zorzano,Mercedes Unzeta,Christian Carpéné +9 more
TL;DR: Results show that human adipocytes express a membrane-bound SSAO that not only readily oxidizes exogenous amines and generates H(2)O(2), but that also interplays with glucose and lipid metabolism by exerting insulin-like actions, which could bring relevant information in pathologies such as obesity or diabetes.
Journal ArticleDOI
Transcriptional Regulation of Adipocyte Hormone-Sensitive Lipase by Glucose
Fatima Smih,Philippe Rouet,Stephanie Lucas,Aline Mairal,Coralie Sengenès,Max Lafontan,Sophie Vaulont,Marta Casado,Dominique Langin +8 more
TL;DR: Hormone-sensitive lipase catalyzes the rate-limiting step in the mobilization of fatty acids from adipose tissue, thus determining the supply of energy substrates in the body, and HSL mRNA was positively regulated by glucose in human adipocytes.