Showing papers by "Fatma M. El-Demerdash published in 2023"
TL;DR: In this article , the authors evaluated the anti-hyperglycemic and antioxidant role of Actinidia deliciosa (kiwifruits) aqueous extract in streptozotocin-treated rats.
2 citations
TL;DR: Wang et al. as mentioned in this paper investigated chemical constituents and coagulant activity of Rubia cordifolia, including 1-hydroxy-2-methyl-9,10-anthraquinone.
Abstract: Rubia cordifolia L. belongs to Rubiaceae family. Its medicinal parts are mainly root and rhizome, which is included in the Chinese Pharmacopoeia (2020), has the effect of cooling blood and stopping bleeding, removing stasis and channeling menstruation. However, studies on the hemostatic effect of R. cordifolia mainly focus on extracts, and the hemostatic components are less studied. Therefore, chemical constituents and coagulant activity of R. cordifolia were investigated in this paper. Eleven compounds were isolated and identified from R. cordifolia, including 1-hydroxy-2-methyl-9,10-anthraquinone (1), 1,4-dihydroxy-2-methylanthraquinone (2), palmitic acid (3), tricosanoic acid (4), ω-hydroxypachybasin (5), ursolic acid (6), oleanolic acid (7), rubilactone (8), β-sitosterol (9), cordifoliol (10), 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone (11). ω-Hydroxypachybasin was isolated from Rubia genus for the first time. 1,4-Dihydroxy-2-methylanthraquinone, rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro, thus indicating that they had procoagulant activity.
TL;DR: Jilin Agriculture Science and Technology College, Jiliin, Jilin Province, China, Environmental Studies Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, HenANET, China as discussed by the authors , Department of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast Ghana, Universidade Federal do Pampa, Uruguaiana, Brazil
Abstract: Jilin Agriculture Science and Technology College, Jilin, Jilin Province, China, Environmental Studies Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan Province, China, Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana, Universidade Federal do Pampa, Uruguaiana, Brazil, Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China
TL;DR: In this paper , a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington's disease (HD) was proposed.
Abstract: Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington’s disease (HD).Methods: We conducted a literature review of the pathophysiology of HD and the limitations of currently available medications. We also reviewed the potential therapeutic benefits of engeletin, a flavanol glycoside, in treating HD through the Keap1/nrf2 pathway. We then proposed a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery across the blood-brain barrier (BBB) and increased bioavailability.Results: HD is an autosomal dominant neurological illness caused by a repetition of the cytosine-adenine-guanine trinucleotide, producing a mutant protein called Huntingtin, which degenerates the brain’s motor and cognitive functions. Excitotoxicity, mitochondrial dysfunction, oxidative stress, elevated concentration of ROS and RNS, neuroinflammation, and protein aggregation significantly impact HD development. Current therapeutic medications can postpone HD symptoms but have long-term adverse effects when used regularly. Herbal medications such as engeletin have drawn attention due to their minimal side effects. Engeletin has been shown to reduce mitochondrial dysfunction and suppress inflammation through the Keap1/NRF2 pathway. However, its limited solubility and permeability hinder it from reaching the target site. A theoretical formulation of engeletin-nanostructured lipid nanocarriers may allow for free transit over the BBB due to offering a similar composition to the natural lipids present in the body a lipid solubility and increase bioavailability, potentially leading to a cure or prevention of HD.Conclusion: The theoretical formulation of engeletin-nanostructured lipid nanocarriers has the potential to improve delivery and increase the bioavailability of engeletin in the treatment of HD, which may lead to a cure or prevention of this fatal illness.
TL;DR: In this paper , the pomegranate peel extract (PGPE) was used to prevent the testicular toxicity and oxidative stress induced by FNP in male Wistar rats.
Abstract: Fenpropathrin (FNP) is one of the commonly used insecticides in agriculture and domestically, leading to environmental and health problems. The goal of the current investigation was to determine how well pomegranate peel extract (PGPE) could prevent the testicular toxicity and oxidative stress induced by FNP. Four groups of male Wistar rats were randomly assigned: negative control (corn oil), PGPE (500 mg/kg BW), positive control (FNP; 15 mg/kg BW, 1/15 LD50), and PGPE + FNP. For four weeks, the rats received their doses daily and orally via gavage. The major phytochemical components (total phenolic, flavonoids, and tannins contents) detected in PGPE by GC-MS included ellagic acid, hydroxymethylfurfurole, guanosine, and pyrogallol with high total phenolic, flavonoids, and tannin contents. FNP-treated rats showed a marked elevation in testicular levels of thiobarbituric acid-reactive substances, hydrogen peroxide, and protein carbonyl content, as well as the activity of aminotransferases and phosphatases. Meanwhile. a significant decline in body weight, gonadosomatic index, glutathione, protein contents, enzymatic antioxidants, and hydroxysteroid dehydrogenase (3β HSD, and 17β HSD) activity was observed. In addition, significant alterations in testicular P53, Cas-3, Bcl-2, IL-β, IL-10, testosterone, follicle-stimulating and luteinizing hormones, and sperm quality were detected. Furthermore, biochemical and molecular changes were corroborated testicular histological abnormalities. Moreover, PGPE-pretreated FNP-intoxicated rats demonstrated considerable improvement in the majority of the studied parameters, when compared to FNP-treated groups. Conclusively, PGPE provided a potent protective effect against the testicular toxicity caused by FNP, due to its antioxidant-active components.
TL;DR: In this article , the authors evaluated the phenotypic antibiotic resistance/sensitivity profiles of probiotic bacteria from human breast milk and evaluated the inhibitory effect of the probiotic organisms against both Gram-negative and Gram-positive bacteria.
Abstract: Background Human life quality and expectancy have increased dramatically over the past 5 decades because of improvements in nutrition and antibiotic's usage fighting against infectious diseases. Yet, it was soon revealed that the microbes adapted to develop resistance to any of the drugs that were used. Recently, there is great concern that commensal bacteria from food and the gastrointestinal tract of humans and animals could act as a reservoir for antibiotic resistance genes. Methodology. This study was intended for evaluating the phenotypic antibiotic resistance/sensitivity profiles of probiotic bacteria from human breast milk and evaluating the inhibitory effect of the probiotic bacteria against both Gram-negative and Gram-positive bacteria. Results The results point out that some of the isolated bacteria were resistant to diverse antibiotics including gentamycin, imipenem, trimethoprim sulfamethoxazole, and nalidixic acid. Susceptibility profile to certain antibiotics like vancomycin, tetracycline, ofloxacin, chloramphenicol, streptomycin, rifampicin, and bacitracin was also observed. The antimicrobial qualities of cell-free supernatants of some probiotic bacteria inhibited the growth of indicator bacteria. Also, antimicrobial properties of the probiotic bacteria from the present study attributed to the production of organic acid, bacterial adhesion to hydrocarbons (BATH), salt aggregation, coaggregation with pathogens, and bacteriocin production. Some isolated bacteria from human milk displayed higher hydrophobicity in addition to intrinsic probiotic properties like Gram-positive classification, catalase-negative activity, resistance to gastric juice (pH 2), and bile salt (0.3%) concentration. Conclusion This study has added to the data of the antibiotic and antimicrobial activity of some probiotic bacteria from some samples of Pakistani women breast milk. Probiotic bacteria are usually considered to decrease gastrointestinal tract diseases by adhering to the gut epithelial and reducing population of pathogens and in the case of Streptococcus lactarius MB622 and Streptococcus salivarius MB620 in terms of hydrophobicity and exclusion of indicator pathogenic strains.