Federica Barbieri

TL;DR: It is demonstrated that 17A expression in neuroblastoma cells enhances the secretion of amyloid β peptide and the Aβ x-42/Α β x-40 peptide ratio and that its synthesis is induced in response to inflammatory stimuli, and correlated, for the first time, to neurodegeneration induced by abnormal GABA B function.

TL;DR: Progress in the identification of chemokine-dependent mechanisms that affect GBM cell survival, trafficking and chemo-attractive functions, opens new perspectives for development of more specific therapeutic approaches that include chemokin-based drugs.

TL;DR: It is demonstrated that SDF-1α induces a dose-dependent proliferation in OC cells, by the specific interaction with CXCR4 and a biphasic activation of ERK1/2 and Akt kinases, suggesting a possible important “cross-talk” between S DF-1/CX CR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer.

TL;DR: Data clearly suggest that metformin exerts antiproliferative activity on glioblastoma cells, showing a higher specificity toward tumor-initiating cells, and that the inhibition of Akt pathway may represent a possible intracellular target of this effect.

TL;DR: Evidence is provided of the expression of multiple CXC chemokines and their receptors in brain tumours and that in particular CXCR4 and SDF1 sustain proliferation and migration of glioma cells to promote malignant progression.