Showing papers in "Experimental Cell Research in 2005"

TL;DR: The activator-type and repressor-type bHLH genes regulate each other, allowing only subsets of cells to undergo differentiation while keeping others to stay neural stem cells.

TL;DR: The data indicate that MSC-induced suppression is a complex mechanism affecting IL-2 and IL-10 signaling and may function differently, depending on T-cell stimuli.

TL;DR: It is suggested that integrity of the functional architecture of the cell nucleus should be used as a read out for cytotoxicity and considered in the development of safe nanotechnology.

TL;DR: The data indicate that circulating fibrocytes contribute to the myofibroblast population in the wounded skin and that they originate from the bone marrow.

TL;DR: Findings in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo.

TL;DR: Mammalian Musashi-1 augments Notch signaling through the translational repression of its target mRNA, m-Numb, thereby contributing to the self-renewal of NSCs.

TL;DR: The data indicate that adiponectin induces human osteoblast proliferation and differentiation, and the proliferation response is mediated by the AdipoR/JNK pathway, while the differentiation response ismediated via the AdipsinoR/p38 pathway.

TL;DR: HMSCs derived from adult human adipose tissue can be differentiated into fully functional adipocytes with a similar, if not identical, phenotype as that observed in cells derived from BM-hMSCs, which could constitute an efficient and easily obtainable renewable cellular source for studies of adipocyte biology.

TL;DR: The first non-hematopoietic mesenchymal stem cells (MSCs) were discovered by Friedenstein in 1976 and it is demonstrated that multi-potent MSCs can be recovered from a variety of other adult tissues and differentiate into numerous tissue lineages including myoblasts, hepatocytes and possibly even neural tissue.

TL;DR: It is emphasized how Wnt signaling is able to maintain a stem cell/progenitor phenotype in normal intestinal crypts, and to impose a very similar phenotype onto colorectal adenomas.

TL;DR: The basis of regeneration in the OE appears to be a population of stem cells, which resides within a microenvironment (niche) consisting of factors crucial for maintenance of its capacity for proliferation and differentiation.

TL;DR: There was a correlation between elevated levels of HA synthesis, CD44 expression and cancer cell migration thereby highlighting the pivotal role that HA metabolism plays in the aggressive breast cancer phenotype.

TL;DR: This work has shown that inhibition of the ERK pathway in achondroplastic mice has provided hope for an approach to the treatment of dwarfism and the role of FGFR3 in epithelial cancers (bladder and cervix) is not known.

TL;DR: The restricted normal tissue distribution of B7-H4, its overexpression in a majority of breast and ovarian cancers and functional activity in transformation validate this cell surface protein as a new target for therapeutic intervention.

TL;DR: The results suggest that dlk functionally interacts in vivo with Notch1, which may lead to the regulation of differentiation processes modulated by Notch 1 activation and signaling, including adipogenesis.

TL;DR: The results indicate that certain, especially cancer-related, MMP family members can generate biologically active endostatin-containing polypeptides from collagen XVIII and thus, by releasing endstatin fragments, may participate in the inhibition of endothelial cell proliferation, migration and angiogenesis.

TL;DR: It is concluded that the activation of PPARγ prevents Aβ-induced neurodegeneration by a mechanism that may involve a cross talk between neuronal PParγ and the Wnt signaling pathway.

TL;DR: The growth inhibitory effect of Herceptin on c-erbB2 overexpressing breast cancer cells is considerably modulated by EGFR coexpression and consequently EGFR/c-erb B2 homo- and heterointeractions, as well as the presence or absence of growth factors.

TL;DR: The CXCL12/CX CR4 system is an important mediator of invasion and metastasis of CXCR4 expressing CRC cells.

TL;DR: It is shown here that membrane ruffles differ from the underlying cell lamella by more densely packed bundles of actin filaments that are enriched in the actin cross- linkers filamin and ezrin, pointing to a specific bundling process based on these cross-linkers.

TL;DR: It is illustrated that adult NSCs can survive and differentiate in the injured inner ear and the feasibility of gene transfer to generate specific progeny for cell replacement therapy in the inner ear is demonstrated.

TL;DR: Dual-color fluorescence in situ hybridization analyses revealed that anaphase bridges were most frequently severed in their middle irrespective of their lengths, which suggests that a structurally fragile site exists in the middle of the anaphASE bridge.

TL;DR: In this review, a comprehensive search of genome databases was performed and the location of previously characterized and predicted genes within the human, mouse, and rat HIN-200 loci were determined.

TL;DR: These results demonstrate for the first time differential effects of SS and CS on Rho and Rac activation, FA redistribution, site-specific FAK phosphorylation, and link them with SS-mediated barrier enhancement, and suggest common signaling and cytoskeletal mechanisms shared by mechanical and chemical factors involved in EC barrier regulation.

TL;DR: It is demonstrated that SDF-1α induces a dose-dependent proliferation in OC cells, by the specific interaction with CXCR4 and a biphasic activation of ERK1/2 and Akt kinases, suggesting a possible important “cross-talk” between S DF-1/CX CR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer.

TL;DR: Evidence for direct protein-protein interactions between EpCAM and claudin-7 was obtained by co-immunoprecipitation after treatment of tumor cells with a membrane-permeable chemical cross-linker.

TL;DR: This method is able to detect an intermediate degree of mtDNA depletion in living cells, and can be used to detect mtDNA free cells (rho0 cells) in culture even at very low numbers.

TL;DR: It is shown that SMN and profilin II co-localise in the cytoplasm of differentiating rat PC12 cells and in neurite-like extensions, especially at their growth cones, which suggests that reduced SMN in SMA might cause axonal pathfinding defects by disturbing the normal regulation of microfilament growth by profilins.

TL;DR: It is suggested that the production of GCP-2 by endothelial cells within the tumor can contribute to tumor development through neovascularization due to endothelial cell chemotaxis and to tumor cell invasion and metastasis by attracting and activating neutrophils loaded with proteases that promote matrix degradation.

TL;DR: Using chromatin immunoprecipitation analysis, data establish Kaiso as a sequence-specific transcriptional repressor of the matrilysin promoter, and suggest that p120ctn and beta-catenin act in a synergistic manner, via distinct mechanisms, to activate matri Lyonsin expression.