Federica Rizzo

TL;DR: The feasibility of generating patient-specific iPSCs and their motor neuron progeny that are genetically corrected and free of exogenous sequences is demonstrated and the potential of this approach for clinical translation is suggested.

TL;DR: Dedifferentiation of human cortical astrocytes is shown into the neural stem/progenitor phenotype to obtain progenitor and mature cells with a neural fate and methylation analysis showed that epigenetic modifications underlie this process.

TL;DR: Mutations in the gene encoding MFN2 are associated with Charcot-Marie-Tooth disease type 2A (CMT2A), a neurological disorder characterized by a wide clinical phenotype that involves the central and peripheral nervous system and may also lead to the identification of related therapeutic targets.

TL;DR: An overview of the basic molecular mechanisms involved in mitochondrial fusion and the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics is provided and the literature describing the main disorders associated with the disruption of mitochondrial fusion is reviewed.

TL;DR: It is concluded that minimally invasive injections of iPSC-derived NSCs can exert a therapeutic effect in ALS, and contributes to advancements in iPSCs-mediated approaches for treating ALS and other neurodegenerative diseases.