F
Federica Sentinelli
Researcher at Sapienza University of Rome
Publications - 49
Citations - 1579
Federica Sentinelli is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 20, co-authored 47 publications receiving 1430 citations. Previous affiliations of Federica Sentinelli include University of Cagliari.
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Journal ArticleDOI
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.
Stefano Romeo,Federica Sentinelli,Satya Dash,Giles S.H. Yeo,David B. Savage,Frida Leonetti,Danila Capoccia,Michela Incani,Cristina Maglio,M. Iacovino,Stephen O'Rahilly,Marco Giorgio Baroni +11 more
TL;DR: Obese Southern Europeans carrying the 148M allele have increased indices of liver damage uncoupled from proxy measures of insulin resistance.
Journal ArticleDOI
The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
Stefano Romeo,Stefano Romeo,Federica Sentinelli,Valentina M. Cambuli,Michela Incani,Tiziana Congiu,Vanessa Matta,Sabrina Pilia,Isabel Huang-Doran,Efisio Cossu,Sandro Loche,Marco Giorgio Baroni +11 more
TL;DR: The data show that the PNPLA3 gene I148M variant is associated with increased levels of ALT/AST in obese children and adolescents, suggesting that it confers genetic susceptibility to liver damage from a young age.
Journal ArticleDOI
Association of the human adiponectin gene and insulin resistance
Emanuela Filippi,Federica Sentinelli,Vincenzo Trischitta,Stefano Romeo,Marcello Arca,Frida Leonetti,Umberto Di Mario,Marco Giorgio Baroni +7 more
TL;DR: Among leaner individuals, the adiponectin gene appears to determine an increased risk to develop insulin resistance, and this association is modulated by body mass index (BMI) levels.
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The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age ≤50 years)
Emanuela Filippi,Federica Sentinelli,Stefano Romeo,Marcello Arca,Andrea Berni,Claudio Tiberti,Antonella Verrienti,Marzia Fanelli,Mara Fallarino,Giovanni Sorropago,Marco Giorgio Baroni,Marco Giorgio Baroni +11 more
TL;DR: The significant association of the adiponectin gene in subjects with early-onset CAD also suggests that that genetic factors for late-ONSet diseases may exert a greater influence in younger persons, when other risk factors are not as prevalent as in older age groups.
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Human Resistin Gene, Obesity, and Type 2 Diabetes: Mutation Analysis and Population Study
Federica Sentinelli,Stefano Romeo,Marcello Arca,Emanuela Filippi,Frida Leonetti,Michela Banchieri,Umberto Di Mario,Marco Giorgio Baroni +7 more
TL;DR: The data suggest that genetic defects of the resistin gene are unlikely to play a role in the etiology of insulin resistance and type 2 diabetes and obesity in the population.