Showing papers in "Journal of Hepatology in 2010"

TL;DR: There is a clear rationale for the management of ascites in patients with cirrhosis, as successful treatment may improve outcome and symptoms, and patients with ascites should generally be considered for referral for liver transplantation.

TL;DR: This poster presents a meta-modelling procedure called “spot-spot analysis” that allows for the direct comparison of the response of the immune system to various types of carbohydrates and its role in disease.

TL;DR: LS is a direct function of central venous pressure which should be considered when assessing the degree of fibrosis, and is measured in 10 patients with decompensated congestive heart failure before and after recompensation.

TL;DR: The diagnostic accuracy of non-invasive tests was high for cirrhosis, but poor for significant fibrosis, and liver biopsy is warranted to diagnose intermediate stages of fibrosis.

TL;DR: Chronic hepatitis B patients receiving medium-term nucleos(t)ide analogue therapy had a significantly lower incidence of HCC compared to untreated patients but treatment does not completely eliminate the risk of H CC.

TL;DR: It is shown that hepatic mitochondrial dysfunction precedes the development of NAFLD and insulin resistance in the OLETF rats, and evidence suggests that progressive mitochondrial dysfunction contributes to the natural history of obesity-associated NA FLD.

TL;DR: Findings may have important implications for understanding the natural history of HBV-infection and for using quantitative HBsAg as a diagnostic tool, i.e. as a marker for predictingHBV-reactivation.

TL;DR: The evidence implicating chronic HBV infection as a causal risk factor of primary liver cancer is discussed and the molecular mechanisms that are critical for the tumourigenic process due to long lasting infection with HBV are discussed.

TL;DR: In liver ischemia reperfusion injury, autophagy mainly has a prosurvival activity allowing the cell for coping with nutrient starvation and anoxia, and in α-1-antitrypsin deficiency, the aggregation-prone ATZ protein accumulates in the endoplasmic reticulum and activates the autophagic response which aims at degrading mutant ATZ.

TL;DR: The results support the role of FGF21 as a key regulator of hepatic lipid metabolism in humans, and suggest that serum FGF 21 can be potentially used as a biomarker for NAFLD.

TL;DR: Baseline HBsAg quantification may help refine future treatment algorithms for both immune-modulator therapy and oral nucleos(t)ide analogue therapy in the setting of the various phases of chronic hepatitis B.

TL;DR: SVR has a strong independent positive influence on the incidence of HCC and on the prognosis of these patients and is achieved in one-third of patients with HCV-related cirrhosis treated with peginterferon and ribavirin.

TL;DR: Let-7 microRNAs negatively regulate Bcl-xL expression in human hepatocellular carcinomas and induce apoptosis in cooperation with an anti-cancer drug targeting Mcl-1.

TL;DR: DGE-MRI is the most accurate method for the diagnosis and quantitative estimation of HS and may be the preferred imaging examination for the non-invasive assessment of HS.

TL;DR: A multidisciplinary panel of experts critically reviewed the current data concerning pathophysiology and clinical consequences of hemostatic disorders in patients with liver disease and suggested that the situation is more complex than previously thought.

TL;DR: Maternal obesity programs development of a dysmetabolic and NAFLD phenotype, which is critically dependent on the early postnatal period and possibly involving alteration of hypothalamic appetite nuclei signalling by maternal breast milk and neonatal adipose tissue derived, leptin, is studied.

TL;DR: RFA seems to be a superior ablative therapy than PEI for HCC, particularly for tumours >2 cm, and PAI needs re-evaluation versus both PEI and RFA for tumour 2 cm.

TL;DR: Semiannual surveillance increases the detection rate of very early hepatocellular carcinomas and reduces the number of advanced tumors as compared to the annual program, which translates into a greater applicability of effective treatments and into a better prognosis.

TL;DR: One-year initial ETV therapy was similarly effective in both compensated and decompensated liver disease HBV patients, and improved underlying liver function in decompensate patients.

TL;DR: Current knowledge on the epidemiology, ethiopathogenesis, clinical, and therapeutic aspects of primary biliary cirrhosis is summarized.

TL;DR: Liver grafts from anti- HBc positive donors can be safely used, preferentially in HBsAg-positive or anti-HBc/anti-HBs positive recipients, while both anti-HSB virus infection after liver transplantation with such grafts and the effect of prophylaxis are evaluated.

TL;DR: Two F4/80(+) Kupffer cell subsets may exist, a CD68(+) subset with phagocytic activity and a CD11b(+,) subset with cytokine-producing capacity.

TL;DR: Interventions that target these vascular structural changes have beneficial effects on portal hypertension and fibrosis in some animal studies which has stimulated interest for pursuing parallel studies in humans with portal hypertension.

TL;DR: An inflammatory immune microenvironment within HCC tumours could be an important means to control tumour progression via TIL activation and proliferation.

TL;DR: Since conventional urinary markers are biased in cirrhosis, a biopsy is the only way to document and quantify renal lesions; moreover, transvenous route should be preferred to percutaneous route.

TL;DR: The deregulation of the expression of the let-7 family of miRNAs by HBx may represent a potential novel pathway through which HBx acts to deregulate cell proliferation leading to hepatocarcinogenesis.

TL;DR: In this article, an integrative molecular dissection of the IGF axis was conducted in a cohort of 104 HCCs analyzing gene and miRNA expression, structural aberrations, and protein activation.

TL;DR: Sorbenib induces the suppression of collagen accumulation and HSC growth warranting the use of sorafenib as a potential therapeutic agent in the treatment of liver fibrosis.

TL;DR: Although the number of liver biopsies avoided does not differ between algorithms for diagnosing cirrhosis, it is significantly higher with Castera algorithm than SAFE biopsy for significant fibrosis, and both algorithms are effective for non-invasive staging of liver fibrosis in chronic hepatitis C.

TL;DR: These data suggest palmitoleate inhibits lipoapoptosis by blocking endoplasmic reticulum stress-associated increases of the BH3-only proteins Bim and PUMA.