F
Feili Gong
Researcher at Huazhong University of Science and Technology
Publications - 90
Citations - 1891
Feili Gong is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 25, co-authored 89 publications receiving 1535 citations. Previous affiliations of Feili Gong include Chinese Ministry of Education.
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Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2 α –mediated tumor progression
Na Liu,Jing Luo,Dong Kuang,Sanpeng Xu,Yaqi Duan,Yu Xia,Zhengping Wei,Xiuxiu Xie,Bingjiao Yin,Fang Chen,Shunqun Luo,Huicheng Liu,Jing Wang,Kan Jiang,Feili Gong,Zhaohui Tang,Xiang Cheng,Huabin Li,Zhuoya Li,Arian Laurence,Guoping Wang,Xiang-Ping Yang +21 more
TL;DR: Lactate, a metabolite found in high concentration within the anaerobic tumor environment, activated mTORC1 that subsequently suppressed TFEB-mediated expression of the macrophage-specific vacuolar ATPase subunit ATP6V0d2, highlighting the ability of tumor cells to modify the function of tumor-infiltrating macrophages to optimize the microenvironment for tumor growth.
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Neutralization of the extracellular HMGB1 released by ischaemic-damaged renal cells protects against renal ischaemia–reperfusion injury
Junhua Li,Quan Gong,Shan Zhong,Lu Wang,Hui Guo,Ying Xiang,Tomas E Ichim,Cong-Yi Wang,Cong-Yi Wang,Shi Chen,Shi Chen,Feili Gong,Gang Chen,Gang Chen +13 more
TL;DR: Data suggest that released HMGB1 by ischaemic renal parenchyma cells may act as an essential early mediator in delayed inflammatory response during IRI, and targetingHMGB1 may represent a potential approach in the prevention of clinical IRI associated with kidney transplantation.
Journal Article
HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.
TL;DR: The advancement of HMGB1 in the pathogenesis of autoimmune initiation and progression during T1D development, as well as islet allograft rejection of diabetic patients after islet transplantation are summarized and updated.
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IL-33 prolongs murine cardiac allograft survival through induction of TH2-type immune deviation.
Hui Yin,Xiangyong Li,Xiaobao Jin,Bobin Zhang,Quan Gong,Heng Yang,Fang Zheng,Feili Gong,Jiayong Zhu +8 more
TL;DR: It is demonstrated that IL-33 serves as a potent inducer of Th2 immune response and can markedly contribute to the prolongation of cardiac allograft survival.
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Carbon monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemia–reperfusion injury
Yongle Ruan,Lu Wang,Yue Zhao,Ying Yao,Song Chen,Junhua Li,Hui Guo,Changsheng Ming,Changsheng Ming,Shi Chen,Shi Chen,Feili Gong,Gang Chen,Gang Chen +13 more
TL;DR: CorM-2-delivered CO protects against lethal renal ischemia-reperfusion injury, and this protection is correlated with the prevention of HMGB1 nuclear-cytoplasmic translocation and release.