Guoping Wang

TL;DR: It is shown that pathways related to neutrophil activation and pulmonary fibrosis are among the major up-regulated transcriptional signatures in lung tissue obtained from patients who died of COVID-19 in Wuhan, China, which suggests that the patient deaths may be related to the host response rather than an active fulminant infection.

TL;DR: Lactate, a metabolite found in high concentration within the anaerobic tumor environment, activated mTORC1 that subsequently suppressed TFEB-mediated expression of the macrophage-specific vacuolar ATPase subunit ATP6V0d2, highlighting the ability of tumor cells to modify the function of tumor-infiltrating macrophages to optimize the microenvironment for tumor growth.

TL;DR: It is demonstrated that SCF/c-kit signaling may mediate the migration of CSCs via activation of p38 MAPK.

TL;DR: AKI was a common and multifactorial complication in patients critically ill with COVID-19 at the late stage of the disease course, and KDIGO stage 3 AKI independently predicted death.

TL;DR: The present study indicated that SDF-1/CXCR4 or CXCR7/Akt and SDF/CxCR4/ERK pathway played important roles in CSCs migration.