Felicia Antohe

TL;DR: Ex vivo placental analyses of the maternofetal transfer of a recombinant, humanized IgG1 antibody in which His435 has been mutated to alanine demonstrate that binding of an IgG to FcRn is a prerequisite for transport across the perfused placenta.

TL;DR: The data demonstrate that FcRn is expressed in functionally active form in endothelial cells, indicating that these cells are a possible site at which serum IgG homeostasis is maintained.

TL;DR: The cell biological findings that revealed that endothelial cell have the attributes to fulfill the transport function are discussed, mainly the results obtained indicate that transcytosis of albumin, low‐density lipoproteins, metaloproteases, and insulin, is performed by cargo‐vesicles and their generated channels.

TL;DR: The results showed that FcRn is expressed by human placental endothelial cells, in a functionally active form, and transcytosis of IgG in HPEC is a time-dependent process that takes place preferentially from the basolateral to the apical compartment, chloroquine sensitive.

TL;DR: It is suggested that enoxaparin reduces the high glucose-induced activation of endothelial cells by inhibiting monocyte adhesion through a mechanism that involves cell adhesion molecules and NF-kappaB.