Felipe V. Gomes

TL;DR: Recent in vivo studies indicating that the mechanisms responsible for CBD therapeutic potential are not unitary but rather depend on the behavioural response being measured suggest activation of TRPV1 channels may help to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD.

TL;DR: The source and targets of neurochemical inputs to BNST subregions and their role in control of autonomic and neuroendocrine function is discussed in details.

TL;DR: These results give further support to the proposal that BNST is involved in the anxiolytic-like effects of CBD observed after systemic administration, probably by facilitating local 5-HT1A receptor-mediated neurotransmission.

TL;DR: Results indicated that CBD and paroxetine decrease the number of buried marbles in the MBT through distinct pharmacological mechanisms, and suggest a potential role of drugs acting on the cannabinoid system in modulating compulsive behaviour.

TL;DR: It was found that CBD modulates cell fate regulatory pathways such as autophagy and others critical pathways for neuronal survival in Neurodegenerative experimental models, suggesting the potential benefit of CBD treatment for psychiatric/cognitive symptoms associated with neurodegeneration.