F
Felix Hoppe-Seyler
Researcher at German Cancer Research Center
Publications - 83
Citations - 3931
Felix Hoppe-Seyler is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer cell & RNA interference. The author has an hindex of 33, co-authored 81 publications receiving 3584 citations.
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Journal ArticleDOI
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.
Karin Butz,Tutik Ristriani,Arnd Hengstermann,Claudia Denk,Martin Scheffner,Felix Hoppe-Seyler +5 more
TL;DR: Findings show that RNAi provides a powerful molecular strategy to inactivate intracellular E6 function efficiently, and define E6 as a most promising therapeutic target to eliminate HPV-positive tumour cells specifically by RNAi.
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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
TL;DR: These results provide direct experimental evidence that the HPV E6 oncoprotein has antiapoptotic activity in HPV-positive tumor cells that is required for their survival.
Journal ArticleDOI
The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets
TL;DR: Hypoxic HPV-positive cancer cells could be a major obstacle for treatment strategies targeting E6/E7 since they downregulate E6 /E7 but evade senescence through hypoxia-induced mTOR impairment, and prospective E6-E7 inhibitors may benefit from a combination with treatment strategies directed against hypoxic tumor cells.
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Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells
Anja Honegger,Daniela Schilling,Sandra Bastian,Jasmin Sponagel,Vladimir Kuryshev,Holger Sültmann,Martin Scheffner,Karin Hoppe-Seyler,Felix Hoppe-Seyler +8 more
TL;DR: It is shown that sustained E6/E7 expression is required to maintain the intracellular levels of members of the miR-17~92 cluster, which reduce expression of the anti-proliferative p21 gene in HPV-positive cancer cells.
Journal Article
Functional p53 protein in human papillomavirus-positive cancer cells.
TL;DR: The results indicate that the tumorigenic phenotype of HPV-positive cancer cell lines does not necessarily correlate with a lack of basal or DNA damage induced p53 activities and that therefore the presence of high risk HPV sequences is not functionally equivalent to the loss of p53 function through somatic mutations of the p53 gene.