F
Feng Gu
Researcher at W. R. Grace and Company
Publications - 30
Citations - 490
Feng Gu is an academic researcher from W. R. Grace and Company. The author has contributed to research in topics: Nanotube & DNA damage. The author has an hindex of 9, co-authored 30 publications receiving 478 citations. Previous affiliations of Feng Gu include University of Missouri & Cabot Corporation.
Papers
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Journal ArticleDOI
Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo.
TL;DR: Three single-stranded DNA genomes that contain the 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) oxidation products oxaluric acid, oxazalone, and cyanuric Acid are constructed to establish a model whereby the modestly mutagenic primary lesion 8-OxodG is oxidized in vivo to much more highly mutagenics secondary lesions.
Patent
Modified colorants and inkjet ink compositions comprising modified colorants
Feng Gu,James A. Belmont,Elizabeth G. Burns,Paul S. Palumbo,Barry B. Corden,Yuan Yu,Ervina Halim +6 more
TL;DR: In this paper, a modified colorant comprising a colorant having attached at least one organic group is described, and various uses for these modified colorants, including inkjet ink compositions.
Journal ArticleDOI
Peroxynitrite-Induced Reactions of Synthetic Oligo 2‘-Deoxynucleotides and DNA Containing Guanine: Formation and Stability of a 5-Guanidino-4-nitroimidazole Lesion†
Feng Gu,W. G. Stillwell,John S. Wishnok,Anthony J. Shallop,Roger A. Jones,Steven R. Tannenbaum +5 more
TL;DR: The results suggest that nuclear DNA containing 5-guanidino-4-nitroimidazole may not be quickly repaired by DNA repair enzyme systems and that this lesion is a potential DNA replication blocker when polymerization is catalyzed by polymerase alpha and polymerase I but not with human polymerase beta.
Journal ArticleDOI
Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations
Paul T. Henderson,William L. Neeley,James C. Delaney,Feng Gu,Jacquine C. Niles,Sang Soo Hah,Steven R. Tannenbaum,John M. Essigmann +7 more
TL;DR: The mutagenic properties of Ua in DNA were investigated using a M13mp7L2 bacteriophage genome containing Ua at a specific site and it is suggested that Ua is instructional, meaning that the shape of the lesion and its interactions with DNA polymerases influence which nucleotide is inserted opposite the lesions during replication and that the instructional nature of theLesion is modulated by the size of the binding pocket of the DNA polymerase.
Patent
Modified pigments having reduced phosphate release, and dispersions and inkjet ink compositions therefrom
TL;DR: In this paper, a modified pigment comprising a pigment having attached at least one geminal bisphosphonic acid group, partial esters thereof, or salts thereof is described. But the modified pigments have a low phosphate release value.