S
Steven R. Tannenbaum
Researcher at Massachusetts Institute of Technology
Publications - 450
Citations - 41328
Steven R. Tannenbaum is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Nitric oxide & DNA damage. The author has an hindex of 87, co-authored 449 publications receiving 39074 citations. Previous affiliations of Steven R. Tannenbaum include College of Health Sciences, Bahrain & Harvard University.
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Journal ArticleDOI
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Laura C. Green,David A. Wagner,Joseph A. Glogowski,Paul L. Skipper,John S. Wishnok,Steven R. Tannenbaum +5 more
TL;DR: A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described.
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DNA damage and mutation in human cells exposed to nitric oxide in vitro.
TL;DR: Experiments in which NO was added to intact human cells and to aerobic solutions of DNA, RNA, guanine, or adenine produced a 40- to 50-fold increase in hypoxanthine and xanthine in cellular DNA, which are believed to account for the mutagenicity of nitric oxide toward bacteria and mammalian cells.
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A model for gastric cancer epidemiology.
TL;DR: It is postulated that one major subtype of gastric carcinoma ("intestinal type") is the end- result of a series of mutations and cell transformation begun in the first decade of life, which allows the cell to become autonomous and invade other tissues.
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Nitrate biosynthesis in man.
Laura C. Green,K Ruiz de Luzuriaga,David A. Wagner,William M. Rand,Nawfal W. Istfan,Vernon R. Young,Steven R. Tannenbaum +6 more
TL;DR: Nitrate metabolism was investigated in long-term metabolic studies in healthy young men under conditions of constant low ingestion, and showed that the source of the excess nitrate in urine was the endogenous biosynthesis of nitrate, rather than the emptying of a body pool.
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Reactive nitrogen species in the chemical biology of inflammation.
TL;DR: This review will focus on recent advances in understanding of the protein and DNA damage caused by reactive nitrogen species produced by macrophages and neutrophils, with emphasis on nitric oxide, nitrous anhydride, peroxynitrite, and nitrogen dioxide radical.