Fengchao Wang

TL;DR: Results indicate that pac litaxel-induced expression of PDK2 serves as an important mechanism for acquired paclitaxel resistance of lung cancer cells, and highlight the importance ofPDK2 for potential therapeutic interventions in patients who have developed a resistance to paclitAXel.

TL;DR: Observations show that PKM2 activates both glycolysis and lipid synthesis, thereby regulating cell proliferation and invasion, thereby providing the basic data required for the development of PKM 2-targeted gene therapy.

TL;DR: In this paper , the influence of TLR4 on the shaping of intestinal microbiota and immune responses during colon inflammation remains poorly characterized, and the authors investigated whether the different susceptibilities to colitis between wild-type (WT) and TL-like receptor 4 −/− mice were gut microbiota-dependent and aimed to identify the potential immunity modulation mechanism.

TL;DR: There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs 1447295 might serve as a reliable biomarker for prostate cancer diagnosis.

TL;DR: In this article , the authors investigate the functions of inflammatory factors and serum markers that participate in disease progression and find that inflammatory factors have the potential to either enhance the efficiency of host immune responses or damage the host organs with immune overreaction in COVID-2019.