Ferdinando Frigeri

TL;DR: The data now provide a molecular diagnostic marker for CML-N, and they are consistent with the notion that the inclusion or exclusion of BCR exons in the fusion protein affects dramatically its capacity to derange myeloid proliferation and differentiation, leading to the appearance of different disease phenotypes.

TL;DR: It is found that the amount of the e1a2 mRNA present in CMLs in chronic phase, although in absolute amount much lower than that present in Ph+ ALLs, represents in most cases approximately 20% to 30% of the total BCR/ABL transcripts.

TL;DR: YIT is well tolerated and achieves high response rates, and individuals in remission 1 year after (90)YIT appear to have long- lasting responses.

TL;DR: Low‐intensity intratechal prophylaxis through liposomal cytarabine was effective because the CNS failure rate was low (3·4%) and without severe neurological toxicities, and improving outcomes in elderly patients remains a priority.

TL;DR: Both regimes showed good tolerability and appealing response rates, but patients continuously relapsed without a clear plateau on survival curves.