F
Fernando Gianfrancesco
Researcher at National Research Council
Publications - 94
Citations - 2697
Fernando Gianfrancesco is an academic researcher from National Research Council. The author has contributed to research in topics: Gene & Paget's disease of bone. The author has an hindex of 24, co-authored 87 publications receiving 2360 citations. Previous affiliations of Fernando Gianfrancesco include American Board of Legal Medicine & International Institute of Minnesota.
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Profilin 1 deficiency drives mitotic defects and impairs genome stability
Federica Scotto di Carlo,Sharon S. Russo,Francesc Muyas,Mariavittoria Mangini,Laura Pazzaglia,Flavia Biamonte,Annarita De Luca,Katia Scotlandi,Isidro Cortes-Ciriano,Fernando Gianfrancesco +9 more
TL;DR: The results indicate that Profilin 1 has a role in regulating cell division, and its inactivation triggers mitotic defects, one of the major mechanisms through which tumour cells acquire chromosomal instability.
Journal ArticleDOI
A mutation in the ZNF687 gene that is responsible for the severe form of Paget’s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model
Sharon S. Russo,Federica Scotto di Carlo,Antonio Maurizi,Giorgio Fortunato,Anna Teti,Danilo Licastro,Carmine Settembre,Tommaso Mello,Fernando Gianfrancesco +8 more
TL;DR: In this article , the first Zfp687 knock-in mouse model was described and demonstrated that the mutation recapitulates the PDB phenotype, resulting in severely altered bone remodeling.
Journal ArticleDOI
The loss of Profilin 1 is a driver of chromosome instability in osteosarcoma
Federica Scotto di Carlo,Sharon S. Russo,Francesc Muyas Remolar,Mariavittoria Mangini,Laura Pazzaglia,Flavia Biamonte,A. De Luca,Katia Scotlandi,Isidro Cortes-Ciriano,Fernando Gianfrancesco +9 more
Posted ContentDOI
The ZNF687 mutation of Paget’s disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional program
Sharon S. Russo,Federica Scotto di Carlo,Giorgio Fortunato,Antonio Maurizi,Anna Teti,Danilo Licastro,Carmine Settembre,Fernando Gianfrancesco +7 more
TL;DR: An essential role is established in the regulation of bone remodelling, and may offer the potential to therapeutically treat Paget’s disease in a PDB mouse model.
Epidemiological,clinical,andgeneticcharacteristicsofPaget's diseaseofboneinaruralareaofCalabria,SouthernItaly
Domenico Rendina,Fernando Gianfrancesco,G. De Filippo,Daniela Merlotti,Teresa Esposito,A. Aloia,Domenico Benvenuto,G. Annunziata,R. Nuti,Pasquale Strazzullo,Giuseppe Mossetti,Luigi Gennari +11 more
TL;DR: The study results confirmed that patients with PDB from ruraldistrict Southern Italy show an earlier onset and an increased clinical sever- ity of the disease that appears mostly independent from the presence of germinal SQSTM1 mutations.