Showing papers by "Fernando Pelaez published in 1998"
TL;DR: Endophytic fungi were isolated from nine plant species growing on gypsum and saline soils in central Spain, showing large differences among isolates from the same species, with respect to their ability to produce metabolites with antimicrobial activity.
137 citations
TL;DR: The continued efforts to discover inhibitors of FPTase have led to the discovery of a triterpenoidal inhibitor, clavaric acid, which inhibits rHFPTase with an IC50 value of 1.3 microM.
Abstract: Farnesyl-protein transferase (FPTase) catalyses the specific transfer of farnesyl to Ras-peptides that is essential for oncogenic activity in oncogene-mediated tumors. Specific inhibition of FPTase activity has been shown to reduce tumor development in nude mice challenged with oncogenic forms of ras, thereby establishing FPTase as a viable therapeutic target. Our continued efforts to discover inhibitors of FPTase has led to the discovery of a triterpenoidal inhibitor, clavaric acid (1). This compound inhibits rHFPTase with an IC50 value of 1.3 microM. Structure elucidation, structure modifications, and biological activity of clavaric acid are herein described.
23 citations
TL;DR: The results show that media with low nitrogen content stimulate the production of antibacterial substances in the genera Amycolatopsis, Saccharomonospora and Saccharopolyspora, while strains from the genus Pseudonocardia produce these metabolites in media with moderate or high nitrogen content.
Abstract: The production of antibacterial substances under different nutritive conditions has been studied in members of the Pseudonocardiaceae family. The results show that media with low nitrogen content stimulate the production of antibacterial substances in the genera Amycolatopsis, Saccharomonospora and Saccharopolyspora, while strains from the genus Pseudonocardia produce these metabolites in media with moderate or high nitrogen content.
20 citations
Patent•
10 Jun 1998TL;DR: Indolylquinones are useful for the treatment and prevention of diabetes mellitus, and in particular for the diagnosis and treatment of hyperglycemia in diabetic patients as mentioned in this paper.
Abstract: Indolylquinones are useful for the treatment and prevention of diabetes mellitus, and in particular, for the treatment or prevention of hyperglycemia in diabetic patients. Some of the indolylquinones are produced by fermentation of the novel fungus Pseudomassaria sp. ATCC 74411.
8 citations
Patent•
02 Jul 1998TL;DR: A compound represented by the formula I was disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof as mentioned in this paper, has inhibitory activity against the oncoprotein Raf.
Abstract: A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf. Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
6 citations