R
Richard G. Ball
Researcher at Merck & Co.
Publications - 142
Citations - 3892
Richard G. Ball is an academic researcher from Merck & Co.. The author has contributed to research in topics: Enantioselective synthesis & Bicyclic molecule. The author has an hindex of 37, co-authored 142 publications receiving 3684 citations. Previous affiliations of Richard G. Ball include University of Rochester & Sunovion.
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Journal ArticleDOI
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
Sheo B. Singh,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Deborah L. Zink,Nancy N. Tsou,Richard G. Ball,Angela Basilio,Olga Genilloud,Maria Teresa Diez,Francisca Vicente,Fernando Pelaez,Katherine Young,Jun Wang +14 more
TL;DR: It was determined that potential reactivity of the enone moiety does not play a key role in the biological activity of platensimycin and cyclohexenone ring conformation renders for the stronger binding interaction with the enzyme.
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Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations
John G. Ondeyka,Gregory L. Helms,Otto D. Hensens,Michael A. Goetz,Deborah L. Zink,Athanasios Tsipouras,Wesley L. Shoop,Lyndia Slayton,Anne W. Dombrowski,Jon D. Polishook,Dan A. Ostlind,Nancy N. Tsou,Richard G. Ball,Sheo B. Singh +13 more
TL;DR: In this paper, a new class of indole terpenes, called nodulisporic acid A (1a), was isolated from fermentations of a Nodulispora sp. The relative and absolute stereochemistry of 1a and its methyl ester, 1b, were independently determined on the basis of ROESY and Jvic evidence.
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Total Synthesis and Determination of the Absolute Configuration of Epibatidine
Stephen Robert Fletcher,Raymond Baker,Mark Stuart Chambers,Richard H. Herbert,Sarah Christine Hobbs,Steven R. Thomas,Hugh M. Verrier,Alan P. Watt,Richard G. Ball +8 more
TL;DR: In this paper, the synthesis of (+)- and (-)-epibatidine (exo-2-(2-chloropyridin-5-yl)-7-azabicyclo[2.2.1]heptane) via reaction of 5-lithio-2-loropyridine with (+)-and (-)-N-BOC-7-AZA-1-one is described.
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Piperidine-ether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements
TL;DR: In this paper, the synthesis of a new series of piperidine-based ethers is described and the relative and absolute stereochemical requirements necessary for high affinity binding to the hNK1 receptor established.
Journal ArticleDOI
Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
Paul J. Coleman,John D. Schreier,Christopher D. Cox,Michael J. Breslin,David B. Whitman,Michael J. Bogusky,Georgia B. McGaughey,Rodney A. Bednar,Wei Lemaire,Scott M. Doran,Steven V. Fox,Susan L. Garson,Anthony L. Gotter,C. Meacham Harrell,Duane R. Reiss,Tamara D. Cabalu,Donghui Cui,Thomayant Prueksaritanont,Joanne Stevens,Pamela L. Tannenbaum,Richard G. Ball,Joyce Stellabott,Steven D. Young,George D. Hartman,Christopher J. Winrow,John J. Renger +25 more
TL;DR: The discovery of a series of α‐methylpiperidine carboxamide dual orexin 1 and orexIn 2 receptor (OX1R/OX2R) antagonists (DORAs) is described, inspired by earlier work from this laboratory in understanding preferred conformational properties for potent Orexin receptor binding.