Fernando R. Moreira

TL;DR: The in vitro antiviral activity and in vivo therapeutic efficacy of GS-621763, an orally bioavailable prodrug ofGS-441524, the parent nucleoside of remdesivir, which targets the highly conserved virus RNA-dependent RNA polymerase of SARS-CoV-2 are demonstrated.

TL;DR: The results suggest that the ability to infect and/or replicate in insect cells is limited after growth in mammalian cells, and underscore the importance of the cells used to produce viral stocks and the potential for adaptation with minimal cell passages.

TL;DR: An Illumina-based sialotranscriptome was reported that allowed finding the missing apyrase from the salivary transcriptome of C. tarsalis, to determine several full-length members of the 34-62 kDa family, when a single EST has been found previously, in addition to identifying manySalivary families with lower expression levels that were not detected previously.

TL;DR: In this article , the authors presented a strategy to discover cytokine surrogate agonists by using modular ligands that exploit induced proximity and receptor dimer geometry as pharmacological metrics amenable to high-throughput screening.

TL;DR: The authors identified and genetically validated an RNA structure (packaging stemloop 2 (PSL2)) that mediates in vitro packaging and in vivo disease and is conserved across all known IAV isolates.