K
Kristen A. Bernard
Researcher at University of Wisconsin-Madison
Publications - 58
Citations - 4867
Kristen A. Bernard is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Virus & Flavivirus. The author has an hindex of 34, co-authored 58 publications receiving 4475 citations. Previous affiliations of Kristen A. Bernard include State University of New York System & New York State Department of Health.
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Journal ArticleDOI
Structure and function of flavivirus NS5 methyltransferase.
Yangsheng Zhou,Debashish Ray,Yiwei Zhao,Hongping Dong,Suping Ren,Suping Ren,Zhong Li,Yi Guo,Kristen A. Bernard,Kristen A. Bernard,Pei Yong Shi,Pei Yong Shi,Hongmin Li,Hongmin Li +13 more
TL;DR: The results demonstrate that the N-7 methylation activity is essential for the WNV life cycle and, thus, methyltransferase represents a novel target for flavivirus therapy.
Journal ArticleDOI
An adenosine nucleoside inhibitor of dengue virus
Zheng Yin,Zheng Yin,Yen Liang Chen,Wouter Schul,Qing Yin Wang,Feng Gu,Jeyaraj Duraiswamy,Ravinder Reddy Kondreddi,Pornwaratt Niyomrattanakit,Suresh B. Lakshminarayana,Anne Goh,Hao Ying Xu,Wei Liu,Boping Liu,Joanne Y.H. Lim,Chuan Young Ng,Min Qing,Chin Chin Lim,Andy Yip,Gang Wang,Wai Ling Chan,Hui Pen Tan,Kai Lin,Bo Zhang,Gang Zou,Kristen A. Bernard,Christine E. Garrett,Karen Beltz,Min Dong,Margaret Weaver,Handan He,Arkadius Pichota,Véronique Dartois,Thomas H. Keller,Pei Yong Shi +34 more
TL;DR: The results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections and suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death.
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West Nile virus infection in birds and mosquitoes, New York State, 2000.
Kristen A. Bernard,Joseph G. Maffei,Susan A. Jones,Elizabeth B. Kauffman,Gregory D. Ebel,Alan P. Dupuis,Kiet A. Ngo,David Nicholas,Donna Young,Pei Yong Shi,Varuni L. Kulasekera,Millicent Eidson,Dennis J. White,Ward B. Stone,Laura D. Kramer +14 more
TL;DR: West Nile (WN) virus was found throughout New York State in 2000, with the epicenter in New York City and surrounding counties, and eight mosquito species, representing four genera, were positive for WN virus.
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Genetic and phenotypic variation of West Nile virus in New York, 2000-2003.
TL;DR: Viral genetic diversity was greater in 2002 and 2003 at both the nucleotide and amino acid levels than in previous years due to the emergence of a new WNV genotype in 2002, and this genotype persisted and became dominant in 2003.
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Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice.
TL;DR: It is proposed that one mechanism of attenuation is rapid viral clearance in vivo due to binding of the virus to ubiquitous heparan sulfate.