F
Fiona E. M. Paulin
Researcher at University of Leicester
Publications - 5
Citations - 554
Fiona E. M. Paulin is an academic researcher from University of Leicester. The author has contributed to research in topics: Untranslated region & Messenger RNA. The author has an hindex of 5, co-authored 5 publications receiving 536 citations. Previous affiliations of Fiona E. M. Paulin include University of Dundee.
Papers
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Journal ArticleDOI
C-Myc 5′ untranslated region contains an internal ribosome entry segment
TL;DR: Data is shown which demonstrates that the 5′ UTR of the proto-oncogene c-myc contains an IRES, the first example of a proto- oncogene regulated in this manner and suggests that aberrant translational regulation of c- myc is likely to play a role in tumorigenesis.
Journal ArticleDOI
A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation.
Stephen A. Chappell,John P. C. Lequesne,Fiona E. M. Paulin,Fiona E. M. Paulin,Matthew L. Deschoolmeester,Mark Stoneley,Mark Stoneley,Richard Soutar,Stuart H. Ralston,Miep H. Helfrich,Anne E. Willis +10 more
TL;DR: The data demonstrate that a single mutation in the c-myc-IRES is sufficient to cause enhanced initiation of translation via internal ribosome entry and represents a novel mechanism of oncogenesis.
Journal Article
Aberrant translational control of the c-myc gene in multiple myeloma.
TL;DR: Aberrant translational control of the c-myc gene in cell lines derived from patients with multiple myeloma is suggested, which may contribute towards pathogenesis of the disease.
Journal ArticleDOI
A single nucleotide change in the c- myc internal ribosome entry segment leads to enhanced binding of a group of protein factors
TL;DR: It is shown by electrophoretic mobility shift assays, north-western blotting and UV cross-linking that radiolabelled c- myc 5' UTR RNA transcripts which harbour the mutation cause enhanced binding of cellular proteins.
Book ChapterDOI
Investigation of Aberrant Translational Control of c-myc in Cell Lines Derived from Patients with Multiple Myeloma
TL;DR: Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and it is demonstrated that this mutation causes altered binding of cellular proteins to this RNA species.