F
Florian Muller
Researcher at Seoul National University
Publications - 6
Citations - 161
Florian Muller is an academic researcher from Seoul National University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 5, co-authored 6 publications receiving 144 citations.
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Journal ArticleDOI
Cardiac glycosides: From molecular targets to immunogenic cell death
TL;DR: This research update summarizes the current knowledge about CGs as new, targeted anti‐cancer agents, alone or in combination with other chemotherapeutic compounds.
Journal ArticleDOI
Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450.
Claudia Cerella,Florian Muller,Anthoula Gaigneaux,Flavia Radogna,Elodie Viry,Sébastien Chateauvieux,Mario Dicato,Marc Diederich +7 more
TL;DR: The results point at Mcl-1 as a ubiquitous factor, downregulated by CGs, whose modulation is essential to achieve cell death.
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2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells.
Cyril Sobolewski,Jiyun Rhim,Noémie Legrand,Florian Muller,Claudia Cerella,Fabienne Mack,Sébastien Chateauvieux,Jeoung-Gyun Kim,Ah-Young Yoon,Kyu-Won Kim,Mario Dicato,Marc Diederich +11 more
TL;DR: 2,5-dimethyl-celecoxib (DMC), which lacks COX-2-inhibitory activity, is found to be able to reduce the growth and induces apoptosis more efficiently than celecoxib in all the leukemic cell lines tested and provides new evidence about the mode of action of this compound on hematologic malignancies.
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Celecoxib prevents curcumin‐induced apoptosis in a hematopoietic cancer cell model
TL;DR: It is shown that curcumin, a polyphenol from Curcuma longa and celecoxib induce apoptosis in hematopoietic cancer cell lines and this natural and synthetic drug combination is detrimental for cell death induction.
Journal ArticleDOI
Effects of Natural Products on Mcl-1 Expression and Function
TL;DR: This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1, one anti-apoptotic protein responsible for cancer cell resistance as it is overexpressed by most cancer cell types.