Elodie Viry

TL;DR: It is demonstrated that hypoxia impairs breast cancer cell susceptibility to NK-mediated lysis in vitro via the activation of autophagy, which provides a cutting-edge advance in the understanding of the mechanism by which hyp oxia-induced autophagic impairs NK-mediation in vitro and paves the way for the formulation of more effective NK cell-based antitumor therapies.

TL;DR: The different mechanisms involved in the TME that affect the anti-tumor immune function of NK cells are summarized.

TL;DR: It is revealed that inhibiting autophagy induces a massive infiltration of natural killer immune cells into the tumor bed, and a subsequent dramatic decrease in the tumor volume of melanomas, highlighting the role of targeting autophile in breaking the immunosuppressive tumor microenvironment barrier.

TL;DR: Tissue-infiltrating chronic lymphocytic leukemia (CLL) cells come in direct contact with both accessory stromal and immune cells that compose the tumor microenvironment (TME).

TL;DR: It is demonstrated that the RCC cell line 786-0 with mutated VHL was resistant to NK-mediated lysis as compared with the VHL-corrected cell line (WT7), and a role for the HIF2α/ITPR1 axis in regulating R CC cell survival is strongly suggested.