F
Floris A. van Gaalen
Researcher at Leiden University Medical Center
Publications - 93
Citations - 4502
Floris A. van Gaalen is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Ankylosing spondylitis & Medicine. The author has an hindex of 23, co-authored 74 publications receiving 3576 citations. Previous affiliations of Floris A. van Gaalen include Loyola University Medical Center.
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Journal ArticleDOI
2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis
Désirée van der Heijde,Sofia Ramiro,Robert Landewé,Xenofon Baraliakos,Filip Van den Bosch,Alexandre Sepriano,Alexandre Sepriano,Andrea Regel,Adrian Ciurea,Hanne Dagfinrud,Maxime Dougados,Maxime Dougados,Floris A. van Gaalen,Pál Géher,Irene E. van der Horst-Bruinsma,Robert D. Inman,Merryn Jongkees,Uta Kiltz,Tore K Kvien,Pedro Machado,Helena Marzo-Ortega,Anna Molto,Anna Molto,Victoria Navarro-Compán,Salih Ozgocmen,Fernando Pimentel-Santos,John D. Reveille,Martin Rudwaleit,Martin Rudwaleit,J. Sieper,Percival D. Sampaio-Barros,Dieter Wiek,Jürgen Braun +32 more
TL;DR: The 2016 Assessment of SpondyloArthritis international Society-EULAR recommendations provide up-to-date guidance on the management of patients with axSpA and three overarching principles and 13 recommendations deal with surgery and spinal fractures.
Journal ArticleDOI
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.
Tom W J Huizinga,Christopher I. Amos,Annette H M van der Helm-van Mil,Wei V. Chen,Floris A. van Gaalen,Damini Jawaheer,Geziena M.Th. Schreuder,Mark H. Wener,Ferdinand C. Breedveld,Naila Ahmad,Raymond F. Lum,René R. P. de Vries,Peter K. Gregersen,René E. M. Toes,Lindsey A. Criswell +14 more
TL;DR: HLA-DRB1 alleles encoding the SE are specific for disease characterized by antibodies to citrullinated peptides, indicating that these alleles do not associate with RA as such, but rather with a particular phenotype.
Journal ArticleDOI
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid Arthritis
Floris A. van Gaalen,Jill van Aken,Tom W J Huizinga,Geziena M.Th. Schreuder,Ferdinand C. Breedveld,E. Zanelli,Walther J. van Venrooij,Cornelis L. Verweij,René E. M. Toes,René R. P. de Vries +9 more
TL;DR: Investigating the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides found that more severe disease progression is found in RA patients with both anti-CCP antibodies and SE alleles.
Journal ArticleDOI
Rheumatoid arthritis is a heterogeneous disease - Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues
Tineke C. T. M. van der Pouw Kraan,Floris A. van Gaalen,Pia V Kasperkovitz,Nicolette L. Verbeet,Tom J. M. Smeets,Maarten C. Kraan,Mike Fero,Paul P. Tak,Tom W J Huizinga,Elsbet J. Pieterman,Ferdinand C. Breedveld,Ash A. Alizadeh,Cornelis L. Verweij,Cornelis L. Verweij +13 more
TL;DR: In this article, complementary DNA microarray analysis was applied to profile gene expression, with a focus on immune-related genes, in affected joint tissues from RA patients and in tissues from osteoarthritis (OA) patients as a control.
Journal ArticleDOI
Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.
Kirsten N Verpoort,Floris A. van Gaalen,Annette H M van der Helm-van Mil,Geziena M.Th. Schreuder,Ferdinand C. Breedveld,Tom W J Huizinga,René R. P. de Vries,René E. M. Toes +7 more
TL;DR: The data show that distinct genetic risk factors are associated with the presence of anti-CCP antibodies in RA and indicate that different pathogenetic mechanisms underlie anti-ccP-positive and anti- CCP-negative RA.