Franca Schmid

TL;DR: The hypothesis that for an efficient oxygen up-regulation at least two regulation mechanisms must be playing hand in hand, namely cerebral blood flow increase and microvascular flow homogenization is supported, however, the contribution of both regulation mechanisms to oxygenUp-regulation likely varies over depth.

TL;DR: This review provides a detailed characterization of the most relevant anatomical and functional features of the cortical vasculature, including a compilation of the available data on laminar variation of vascular density and the topological aspects of the microvascular system.

TL;DR: The results suggest that capillary dilation/constriction offers the potential of being an efficient mechanism to alter the distribution of RBCs locally and hence could be important for the local regulation of oxygen delivery.

TL;DR: In vivo measurements and blood flow simulations in anatomically accurate microvascular network and in silico results suggest that the balancing of outflow velocities contributes to the robustness of perfusion, and provide the first in vivo evidence of the impact of RBC dynamics on the flow field in the cortical microvasculature.

TL;DR: In this paper , the authors conducted cause-and-effect studies by optically ablating pericytes in adult and aged mice in vivo and identified pericyte remodeling as a therapeutic target to preserve capillary flow dynamics.