F
Francesca Faggioli
Researcher at Albert Einstein College of Medicine
Publications - 5
Citations - 286
Francesca Faggioli is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Genome instability & Aneuploidy. The author has an hindex of 5, co-authored 5 publications receiving 241 citations. Previous affiliations of Francesca Faggioli include National Research Council.
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Journal ArticleDOI
Whole Chromosome Instability induces senescence and promotes SASP.
Grasiella A. Andriani,Vinnycius Pereira Almeida,Francesca Faggioli,Maurizio Mauro,Wanxia Li Tsai,Laura Santambrogio,Alexander Y. Maslov,Massimo Gadina,Judith Campisi,Jan Vijg,Cristina Montagna +10 more
TL;DR: The findings suggest that W-CIN triggers premature senescence, presumably to prevent the propagation of cells with an abnormal DNA content, and that aneuploid cells that accumulate during aging in some mammalian tissues potentially contribute to age-related pathologies and inflammation through SASP secretion.
Journal ArticleDOI
Chromosome-specific accumulation of aneuploidy in the aging mouse brain
TL;DR: It is shown that aneuploidy accumulates with age in a chromosome-specific manner, with chromosomes 7, 18 and Y most severely affected, i.e. up to 9.8% of non-neuronal brain nuclei in 28-month-old animals for chromosome 18.
Journal ArticleDOI
Chromosomal aneuploidy in the aging brain.
TL;DR: This work will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies.
Journal ArticleDOI
Cell fusion is a physiological process in mouse liver
TL;DR: By creating chimeric mice bearing distinct reporter genes (LacZ and GFP), it is shown that in an unperturbed setting, hepatocytes carrying both markers can be detected via immunohistochemistry and polymerase chain reaction analysis.
Book ChapterDOI
Four-color FISH for the detection of low-level aneuploidy in interphase cells.
TL;DR: A modification of the standard FISH protocol adapted for the detection of low-frequency mosaic aneuploidy in interphase cells is described, which greatly reduces the enumeration of false-positive signals that are challenging in the enumerations of ploidy changes.