J
Jan Vijg
Researcher at Albert Einstein College of Medicine
Publications - 333
Citations - 18893
Jan Vijg is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Mutation. The author has an hindex of 71, co-authored 311 publications receiving 16461 citations. Previous affiliations of Jan Vijg include University of Texas Health Science Center at San Antonio & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria,Naoko Ohtani,Sameh A. Youssef,Francis Rodier,Wendy Toussaint,James R. Mitchell,Remi-Martin Laberge,Jan Vijg,Harry van Steeg,Martijn E.T. Dollé,Jan H.J. Hoeijmakers,Alain de Bruin,Eiji Hara,Judith Campisi,Judith Campisi +14 more
TL;DR: It is shown that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA).
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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer,George A. Garinis,Anja Raams,Astrid S. Lalai,Andria Rasile Robinson,Esther Appeldoorn,Hanny Odijk,Roos Oostendorp,Anwaar Ahmad,Wibeke J. Van Leeuwen,Arjan F. Theil,Wim Vermeulen,Gijsbertus T. J. van der Horst,Peter Meinecke,Wim J. Kleijer,Jan Vijg,Nicolaas G. J. Jaspers,Jan H.J. Hoeijmakers +17 more
TL;DR: It is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway, which re-allocates resources from growth to somatic preservation and life extension, and demonstrates that ageing and end-of-life fitness are determined both by stochastic damage and genetics.
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Aging and Genome Maintenance: Lessons from the Mouse?
Paul Hasty,Judith Campisi,Judith Campisi,Jan H.J. Hoeijmakers,Harry van Steeg,Jan Vijg,Jan Vijg +6 more
TL;DR: The use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans is discussed.
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Increased cell-to-cell variation in gene expression in ageing mouse heart
Rumana Bahar,Claudia H. Hartmann,Karl A. Rodriguez,Ashley D. Denny,Rita A. Busuttil,Martijn E.T. Dollé,R. Brent Calder,Gary B. Chisholm,Bradley H Pollock,Christoph Klein,Jan Vijg +10 more
TL;DR: The results underscore the stochastic nature of the ageing process, and could provide a mechanism for age-related cellular degeneration and death in tissues of multicellular organisms.
Journal ArticleDOI
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo
J. A. Gossen,W. J.F. De Leeuw,C. H.T. Tan,Ellen C. Zwarthoff,F. Berends,P. H.M. Lohman,D.L. Knook,Jan Vijg +7 more
TL;DR: The value of this transgenic mouse model in studying gene mutations in vivo is demonstrated and could be used as a sensitive, organ-specific, short-term mutagenicity assay in addition to its use in fundamental research.