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Francesca Fernandez-Enright

Researcher at Illawarra Health & Medical Research Institute

Publications -  19
Citations -  469

Francesca Fernandez-Enright is an academic researcher from Illawarra Health & Medical Research Institute. The author has contributed to research in topics: Schizophrenia & Prefrontal cortex. The author has an hindex of 10, co-authored 19 publications receiving 366 citations. Previous affiliations of Francesca Fernandez-Enright include University of Wollongong & Australian Catholic University.

Papers
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Structural contributions of antipsychotic drugs to their therapeutic profiles and metabolic side effects

Somayeh Jafari, +2 more
- 01 Feb 2012 - 
TL;DR: In this paper, the potential role of the chemical structure of atypical antipsychotics in their therapeutic properties and metabolic disturbances is discussed. But, despite their therapeutic benefits, most of these drugs can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases.
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Molecular evidence of synaptic pathology in the CA1 region in schizophrenia

Natalie Matosin, +9 more
TL;DR: A quantitative immunoblot experiment supports the presence of extensive molecular abnormalities to PSD95 and several of its associated proteins in the CA1 region in schizophrenia, offering a small but significant step toward understanding how protein levels in the PSD are altered in the schizophrenia brain, and their relevance to overall hippocampal and cognitive dysfunction in the illness.
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Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.

Natalie Matosin, +6 more
- 01 Nov 2014 - 
TL;DR: The findings suggest that mGluRs are unaltered in the ACC; however, the presence of altered receptor function cannot be discounted and requires further investigation.
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Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Natalie Matosin, +16 more
- 17 Mar 2015 - 
TL;DR: Results from this study provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder.
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Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment.

Natalie Matosin, +4 more
- 15 Mar 2017 - 
TL;DR: The known processes that regulate mGluR5 and those that have already been studied in schizophrenia are summarized, and the consequences of this dysregulation for current mGLUR5 pharmacological strategies are discussed.