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Francesca Gaccioli
Researcher at University of Cambridge
Publications - 50
Citations - 2907
Francesca Gaccioli is an academic researcher from University of Cambridge. The author has contributed to research in topics: Pregnancy & Placenta. The author has an hindex of 27, co-authored 44 publications receiving 2241 citations. Previous affiliations of Francesca Gaccioli include University of Texas Health Science Center at San Antonio & National Institute for Health Research.
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Journal ArticleDOI
Human placenta has no microbiome but can contain potential pathogens.
Marcus C. de Goffau,Marcus C. de Goffau,Susanne Lager,Susanne Lager,Susanne Lager,Ulla Sovio,Ulla Sovio,Francesca Gaccioli,Francesca Gaccioli,Emma Cook,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock,Julian Parkhill,Julian Parkhill,D. Stephen Charnock-Jones,D. Stephen Charnock-Jones,Gordon C. S. Smith,Gordon C. S. Smith +18 more
TL;DR: It is concluded that bacterial infection of the placenta is not a common cause of adverse pregnancy outcome and that the human Placenta does not have a microbiome, but it does represent a potential site of perinatal acquisition of S. agalactiae, a major cause of neonatal sepsis.
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Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies
Nina Jansson,Fredrick J. Rosario,Francesca Gaccioli,Susanne Lager,Helen Jones,Sara Roos,Thomas Jansson,Theresa L. Powell +7 more
TL;DR: Up-regulation of specific placental amino acid transporter isoforms may contribute to fetal overgrowth in maternal obesity, which may be mediated by activation of insulin/IGF-I and mTOR signaling pathways, which are positive regulators of placents amino acid transporters.
Journal ArticleDOI
Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.
Irving L.M.H. Aye,Susanne Lager,Vanessa I. Ramirez,Francesca Gaccioli,Donald J. Dudley,Thomas Jansson,Theresa L. Powell +6 more
TL;DR: It is suggested that inflammatory processes associated with elevated maternal BMI may influence fetal growth by altering placental function and activation of placental inflammatory pathways.
Journal ArticleDOI
Amino Acid Starvation Induces the SNAT2 Neutral Amino Acid Transporter by a Mechanism That Involves Eukaryotic Initiation Factor 2α Phosphorylation and cap-independent Translation
Francesca Gaccioli,Charlie C. Huang,Chuanping Wang,Elena Bevilacqua,Renata Franchi-Gazzola,Gian C. Gazzola,Ovidio Bussolati,Martin D. Snider,Maria Hatzoglou +8 more
TL;DR: In this article, the authors investigated the molecular mechanisms underlying starvation-dependent and hypertonic increase of system A transport activity for neutral amino acids that leads to the recovery of cell volume and amino acid levels once extracellular amino acid availability is restored.
Journal ArticleDOI
Placental transport in response to altered maternal nutrition
TL;DR: It is proposed that the placenta integrates maternal and fetal nutritional cues with information from intrinsic nutrient sensors to balance fetal demand with the ability of the mother to support pregnancy, and plays a critical role in modulating maternal–fetal resource allocation.