S
Susanne Lager
Researcher at Uppsala University
Publications - 51
Citations - 2647
Susanne Lager is an academic researcher from Uppsala University. The author has contributed to research in topics: Placenta & Pregnancy. The author has an hindex of 20, co-authored 44 publications receiving 2031 citations. Previous affiliations of Susanne Lager include University of Cambridge & University of Gothenburg.
Papers
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Journal ArticleDOI
Human placenta has no microbiome but can contain potential pathogens.
Marcus C. de Goffau,Marcus C. de Goffau,Susanne Lager,Susanne Lager,Susanne Lager,Ulla Sovio,Ulla Sovio,Francesca Gaccioli,Francesca Gaccioli,Emma Cook,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock,Julian Parkhill,Julian Parkhill,D. Stephen Charnock-Jones,D. Stephen Charnock-Jones,Gordon C. S. Smith,Gordon C. S. Smith +18 more
TL;DR: It is concluded that bacterial infection of the placenta is not a common cause of adverse pregnancy outcome and that the human Placenta does not have a microbiome, but it does represent a potential site of perinatal acquisition of S. agalactiae, a major cause of neonatal sepsis.
Journal ArticleDOI
Regulation of Nutrient Transport across the Placenta
Susanne Lager,Theresa L. Powell +1 more
TL;DR: Recent studies of regulatory mechanisms that modulate placental transport of amino acids, fatty acids, and glucose are focused on and suggest that changes in placental nutrient transport may directly contribute to the development of abnormal fetal growth.
Journal ArticleDOI
Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies
Nina Jansson,Fredrick J. Rosario,Francesca Gaccioli,Susanne Lager,Helen Jones,Sara Roos,Thomas Jansson,Theresa L. Powell +7 more
TL;DR: Up-regulation of specific placental amino acid transporter isoforms may contribute to fetal overgrowth in maternal obesity, which may be mediated by activation of insulin/IGF-I and mTOR signaling pathways, which are positive regulators of placents amino acid transporters.
Journal ArticleDOI
Recognizing the reagent microbiome.
Marcus C. de Goffau,Susanne Lager,Susannah J. Salter,Josef Wagner,Andreas Kronbichler,D. Stephen Charnock-Jones,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock,Gordon C. S. Smith,Julian Parkhill +10 more
TL;DR: Visual, statistical, methodical and ecological techniques are described to facilitate recognition of signals that represent contamination in the microbiome literature.
Journal ArticleDOI
Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.
Irving L.M.H. Aye,Susanne Lager,Vanessa I. Ramirez,Francesca Gaccioli,Donald J. Dudley,Thomas Jansson,Theresa L. Powell +6 more
TL;DR: It is suggested that inflammatory processes associated with elevated maternal BMI may influence fetal growth by altering placental function and activation of placental inflammatory pathways.